Multi-Species Synbiotic Supplementation Enhances Gut Microbial Diversity, Increases Urolithin A and Butyrate Production, and Reduces Inflammation in Healthy Adults: A Randomized, Placebo-Controlled Trial
Napier B, Allegretti J, Feuerstadt P, Kelly C, Van Hise N, Jäger R, Kassam Z, Reid G. Multi-Species Synbiotic Supplementation Enhances Gut Microbial Diversity, Increases Urolithin A and Butyrate Production, and Reduces Inflammation in Healthy Adults: A Randomized, Placebo-Controlled Trial. Nutrients 2025, 17: 2734. PMID: 40944126, PMCID: PMC12430871, DOI: 10.3390/nu17172734.Peer-Reviewed Original ResearchConceptsPlacebo-controlled trialBiological functionsButyrate levelsButyrate-producing speciesGut microbial diversitySystemic inflammationFecal microbiome compositionFecal butyrate levelsMicrobiome-derived metabolitesUrolithin AButyrate producersAlpha diversityMicrobial diversityBeneficial microbesPrecursor metabolismProbiotic strainsButyrate productionMicrobiome compositionHealthy adultsBaseline day 0Fecal butyrateEnd-of-studyPlacebo-ControlledProbiotic supplementationSerum CRP
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