2021
Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study
Murray K, Lin Y, Makary MM, Whang PG, Geha P. Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study. Molecular Pain 2021, 17: 1744806921990938. PMID: 33567986, PMCID: PMC7883154, DOI: 10.1177/1744806921990938.Peer-Reviewed Original ResearchConceptsChronic low back painOpioid analgesicsCLBP patientsPain patientsChronic low back pain patientsLow back pain patientsBrain structuresOpioid analgesic treatmentBack pain patientsClasses of medicationsChronic pain patientsLow back painLong-term riskAltered brain structureSub-cortical areasOverall significant decreaseEvidence of misuseAnalgesic treatmentChronic treatmentBack painFunctional brain imagingLimbic areasUnmedicated patientsHealthy controlsNucleus accumbens
2020
Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations.
Smith SM, Dworkin RH, Turk DC, McDermott MP, Eccleston C, Farrar JT, Rowbotham MC, Bhagwagar Z, Burke LB, Cowan P, Ellenberg SS, Evans SR, Freeman RL, Garrison LP, Iyengar S, Jadad A, Jensen MP, Junor R, Kamp C, Katz NP, Kesslak JP, Kopecky EA, Lissin D, Markman JD, Mease PJ, O'Connor AB, Patel KV, Raja SN, Sampaio C, Schoenfeld D, Singh J, Steigerwald I, Strand V, Tive LA, Tobias J, Wasan AD, Wilson HD. Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations. Pain 2020, 161: 2446-2461. PMID: 32520773, PMCID: PMC7572524, DOI: 10.1097/j.pain.0000000000001952.Peer-Reviewed Original Research
2012
Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations
Dworkin RH, Turk DC, Peirce-Sandner S, Burke LB, Farrar JT, Gilron I, Jensen MP, Katz NP, Raja SN, Rappaport BA, Rowbotham MC, Backonja M, Baron R, Bellamy N, Bhagwagar Z, Costello A, Cowan P, Fang WC, Hertz S, Jay GW, Junor R, Kerns RD, Kerwin R, Kopecky EA, Lissin D, Malamut R, Markman JD, McDermott MP, Munera C, Porter L, Rauschkolb C, Rice ASC, Sampaio C, Skljarevski V, Sommerville K, Stacey BR, Steigerwald I, Tobias J, Trentacosti AM, Wasan AD, Wells GA, Williams J, Witter J, Ziegler D. Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations. Pain 2012, 153: 1148-1158. PMID: 22494920, DOI: 10.1016/j.pain.2012.03.003.Peer-Reviewed Original ResearchConceptsRecent randomized clinical trialsClinical trialsAnalgesic treatmentChronic pain clinical trialsPain clinical trialsAnalgesic drug developmentChronic pain treatmentChronic pain trialsRandomized clinical trialsAnalgesic clinical trialsNumber of patientsEvidence-based approachIMMPACT recommendationsPain treatmentPain trialsPharmacologic treatmentAnalgesic trialsPain assessmentAssay sensitivityEfficacious medicationsConsensus meetingNegative trialsImproved efficacyStudy designTrials
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