2021
Benefit–risk assessment and reporting in clinical trials of chronic pain treatments: IMMPACT recommendations
Kleykamp BA, Dworkin RH, Turk DC, Bhagwagar Z, Cowan P, Eccleston C, Ellenberg SS, Evans SR, Farrar JT, Freeman RL, Garrison LP, Gewandter JS, Goli V, Iyengar S, Jadad AR, Jensen MP, Junor R, Katz NP, Kesslak JP, Kopecky EA, Lissin D, Markman JD, McDermott MP, Mease PJ, O'Connor AB, Patel KV, Raja SN, Rowbotham MC, Sampaio C, Singh JA, Steigerwald I, Strand V, Tive LA, Tobias J, Wasan AD, Wilson HD. Benefit–risk assessment and reporting in clinical trials of chronic pain treatments: IMMPACT recommendations. Pain 2021, 163: 1006-1018. PMID: 34510135, PMCID: PMC8904641, DOI: 10.1097/j.pain.0000000000002475.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsClinical trialsBenefit-risk assessmentChronic painChronic pain clinical trialsPain clinical trialsDifferent patient subpopulationsChronic pain treatmentKey professional organizationsIMMPACT recommendationsPain treatmentPain assessmentPatient subpopulationsIndividual patientsConsensus meetingSpecific treatmentClinical meaningfulnessRCT resultsTrialsTreatment group levelPainRisk outcomesTreatmentAssessment toolPrimary recommendation
2020
Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations.
Smith SM, Dworkin RH, Turk DC, McDermott MP, Eccleston C, Farrar JT, Rowbotham MC, Bhagwagar Z, Burke LB, Cowan P, Ellenberg SS, Evans SR, Freeman RL, Garrison LP, Iyengar S, Jadad A, Jensen MP, Junor R, Kamp C, Katz NP, Kesslak JP, Kopecky EA, Lissin D, Markman JD, Mease PJ, O'Connor AB, Patel KV, Raja SN, Sampaio C, Schoenfeld D, Singh J, Steigerwald I, Strand V, Tive LA, Tobias J, Wasan AD, Wilson HD. Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations. Pain 2020, 161: 2446-2461. PMID: 32520773, PMCID: PMC7572524, DOI: 10.1097/j.pain.0000000000001952.Peer-Reviewed Original Research
2014
Anti-Hypertensive Medications and Cardiovascular Events in Older Adults with Multiple Chronic Conditions
Tinetti ME, Han L, McAvay GJ, Lee DS, Peduzzi P, Dodson JA, Gross CP, Zhou B, Lin H. Anti-Hypertensive Medications and Cardiovascular Events in Older Adults with Multiple Chronic Conditions. PLOS ONE 2014, 9: e90733. PMID: 24614535, PMCID: PMC3948696, DOI: 10.1371/journal.pone.0090733.Peer-Reviewed Original ResearchConceptsMultiple chronic conditionsAnti-hypertensive treatmentCardiovascular eventsAnti-hypertensive medicationsHigh-intensity groupChronic conditionsOlder adultsHazard ratioPropensity scoreIntensity groupStandardized daily doseCommunity-living participantsPropensity score adjustmentCV eventsMedication intensityLess comorbidityDaily doseRandomized trialsMAIN OUTCOMERepresentative cohortScore adjustmentSurvey cohortRCT resultsCohortMortality
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