2017
Upregulation of Epac-1 in Hepatic Stellate Cells by Prostaglandin E2 in Liver Fibrosis Is Associated with Reduced Fibrogenesis
Schippers M, Beljaars L, Post E, Lotersztajn S, Reker-Smit C, Han B, Munoz-Llancao P, Schmidt M, Poelstra K. Upregulation of Epac-1 in Hepatic Stellate Cells by Prostaglandin E2 in Liver Fibrosis Is Associated with Reduced Fibrogenesis. Journal Of Pharmacology And Experimental Therapeutics 2017, 363: 126-135. PMID: 28864467, DOI: 10.1124/jpet.117.241646.Peer-Reviewed Original ResearchConceptsEpac-1 activationEpac-1Hepatic stellate cellsNiflumic acidPlatelet-derived growth factor-induced proliferationLiver fibrosisFibrotic livers of miceReduced Rho-kinase activityKupffer cellsIsolated hepatic stellate cellsStellate cellsCAMP-mediated effectsGrowth factor-induced proliferationWeeks carbon tetrachlorideEffect of PGE<sub>2</sub> onEPAC-1 expressionKinase activityProtein kinase A expressionRho-kinase activityWestern blot analysisActivity in vitroProstaglandin E<sub>2</sub>Cyclo-oxygenase productsDownstream targetsCell-specific delivery
2013
Sustained delivery of proangiogenic microRNA‐132 by nanoparticle transfection improves endothelial cell transplantation
Devalliere J, Chang WG, Andrejecsk JW, Abrahimi P, Cheng CJ, Jane‐wit D, Saltzman WM, Pober JS. Sustained delivery of proangiogenic microRNA‐132 by nanoparticle transfection improves endothelial cell transplantation. The FASEB Journal 2013, 28: 908-922. PMID: 24221087, PMCID: PMC3898640, DOI: 10.1096/fj.13-238527.Peer-Reviewed Original ResearchConceptsHuman umbilical vein ECsEndothelial cellsMiR-132MicroRNA-132Cultured human umbilical vein endothelial cellsNumber of microvesselsGrowth factor-induced proliferationHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsEndothelial cell transplantationCultured endothelial cellsEndogenous growth factorsEC transplantationVein endothelial cellsCell transplantationImmunodeficient miceTissue perfusionTransplantationMiR deliveryGrowth factorIntegrin αvβ3Endocytosed nanoparticlesSquare millimeterBiological effectsControl transfection
1998
Interferon‐γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
Rincón M, Enslen H, Raingeaud J, Recht M, Zapton T, Su M, Penix L, Davis R, Flavell R. Interferon‐γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. The EMBO Journal 1998, 17: 2817-2829. PMID: 9582275, PMCID: PMC1170622, DOI: 10.1093/emboj/17.10.2817.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcium-Calmodulin-Dependent Protein KinasesCell DivisionEnzyme InhibitorsImidazolesInterferon-gammaLymphocyte ActivationMAP Kinase Kinase 6MiceMice, Inbred C3HMice, Inbred C57BLMice, TransgenicMitogen-Activated Protein Kinasesp38 Mitogen-Activated Protein KinasesPyridinesSignal TransductionTh1 CellsTh2 CellsTranscription, GeneticConceptsP38 MAP kinase pathwayMAP kinase pathwayP38 MAP kinaseMAP kinaseKinase pathwayMAP kinase kinase 6Pyridinyl imidazole compoundsGrowth factor-induced proliferationIFNgamma promoterMammalian cellsSignal transductionEnvironmental stressTransgenic miceTh1 cellsKinase resultsKinase 6Molecular mechanismsTh2 cellsCellular responsesKinaseCell deathInflammatory responseT cellsImmune responsePathway
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