2010
Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction
Roberts B, Holden D, Shaffer C, Seymour P, Menniti F, Schmidt C, Williams G, Castner S. Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction. Behavioural Brain Research 2010, 212: 41-48. PMID: 20347881, DOI: 10.1016/j.bbr.2010.03.039.Peer-Reviewed Original ResearchMeSH Keywordsalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnalysis of VarianceAnimalsAnimals, NewbornArea Under CurveDisease Models, AnimalDose-Response Relationship, DrugDrug Administration ScheduleExcitatory Amino Acid AgonistsKetamineMacaca fascicularisMacaca mulattaMemory DisordersMemory, Short-TermMotor ActivityNeuropsychological TestsReaction TimeSulfonamidesThiophenesTime FactorsConceptsCognitive impairment associated with schizophreniaAlpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acidMemory impairmentN-methyl-D-aspartateCognitive dysfunctionCore aspect of schizophreniaEffects of acute ketamineBehavioral effects of ketaminePositive modulators of AMPA receptorsEffects of positive allosteric modulatorsModel of cognitive dysfunctionAlpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptorsNegative-like symptomsWorking Memory DeficitsWorking memory impairmentModulation of AMPA receptorsEffects of ketaminePositive allosteric modulatorsRegulation of NMDA receptorsGlutamatergic synaptic transmissionAcute ketamineWorking memoryPF-4778574Antagonist ketamineMemory deficits
2002
Visual Perceptual and Working Memory Impairments in Schizophrenia
Tek C, Gold J, Blaxton T, Wilk C, McMahon RP, Buchanan RW. Visual Perceptual and Working Memory Impairments in Schizophrenia. JAMA Psychiatry 2002, 59: 146-153. PMID: 11825136, DOI: 10.1001/archpsyc.59.2.146.Peer-Reviewed Original ResearchConceptsMemory testPerceptual discriminationPerceptual impairmentsImpaired performanceMemory impairmentVisual perceptual discriminationVisual working memoryPerceptual discrimination taskVisual perceptual processingVisual perceptual impairmentsPosterior brain areasWorking memory impairmentSpatial visual perceptionVisual information processingSpatial visual informationPerceptual processingWorking memoryVisual perceptualPerceptual systemDiscrimination taskVisual perceptionVisual stimuliActive maintenanceSpatial testsExtent of impairment
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