Lactobacillus casei Cell Wall Extract and Production of Galactose-Deficient IgA1 in a Humanized IGHA1 Mouse Model
Li R, Wang M, Li J, Zhu L, Xie X, Wang H, Zhang X, Tian W, Zhang Y, Dong Y, Zan J, Li H, Zhang Y, Zhou X, Shi S, Shu C, Liu L, Jin J, Lv J, Zhang H. Lactobacillus casei Cell Wall Extract and Production of Galactose-Deficient IgA1 in a Humanized IGHA1 Mouse Model. Journal Of The American Society Of Nephrology 2024, 36: 60-72. PMID: 39172518, PMCID: PMC11706567, DOI: 10.1681/asn.0000000000000465.Peer-Reviewed Original ResearchLactobacillus casei cell wall extractAssociated with hematuriaGalactose-deficient IgA1Mouse modelIgA nephropathyWild-type C57BL/6J miceFactor H mutationCell wall extractsCFA-treated miceGd-IgA1 levelsElevated levelsGalactose-deficient IgA1 levelsIgA1-immune complexesModel of IgA nephropathyMouse chromosomal lociGlomerular mesangial areasMonths of ageTransgenic mouse modelHuman IgA1Hinge regionHuman IgA1 heavy chainMucosal sitesGd-IgA1Immune reactivityGlomerular alterationsGenetics of IgA nephrology: risks, mechanisms, and therapeutic targets
Qu S, Zhou X, Zhang H. Genetics of IgA nephrology: risks, mechanisms, and therapeutic targets. Pediatric Nephrology 2024, 39: 3157-3165. PMID: 38600219, DOI: 10.1007/s00467-024-06369-7.Peer-Reviewed Original ResearchGenome-wide association studiesPopulation-based genome-wide association studiesComplex multifactorial traitsPolygenic risk scoresRisk lociAssociation studiesTherapeutic targetMultifactorial traitGenetic explorationGenetic researchGenetic causationMolecular mechanismsRisk scoreElevated serum Gd-IgA1 levelsIncreased riskPathogenesis modelGroup of individualsSerum Gd-IgA1 levelsGd-IgA1 levelsMedical treatmentLociGalactose-deficient IgA1RiskGeneticsGd-IgA1
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply