Lactobacillus casei Cell Wall Extract and Production of Galactose-Deficient IgA1 in a Humanized IGHA1 Mouse Model
Li R, Wang M, Li J, Zhu L, Xie X, Wang H, Zhang X, Tian W, Zhang Y, Dong Y, Zan J, Li H, Zhang Y, Zhou X, Shi S, Shu C, Liu L, Jin J, Lv J, Zhang H. Lactobacillus casei Cell Wall Extract and Production of Galactose-Deficient IgA1 in a Humanized IGHA1 Mouse Model. Journal Of The American Society Of Nephrology 2024, 36: 60-72. PMID: 39172518, PMCID: PMC11706567, DOI: 10.1681/asn.0000000000000465.Peer-Reviewed Original ResearchLactobacillus casei cell wall extractAssociated with hematuriaGalactose-deficient IgA1Mouse modelIgA nephropathyWild-type C57BL/6J miceFactor H mutationCell wall extractsCFA-treated miceGd-IgA1 levelsElevated levelsGalactose-deficient IgA1 levelsIgA1-immune complexesModel of IgA nephropathyMouse chromosomal lociGlomerular mesangial areasMonths of ageTransgenic mouse modelHuman IgA1Hinge regionHuman IgA1 heavy chainMucosal sitesGd-IgA1Immune reactivityGlomerular alterations
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