2024
Genetics of IgA nephrology: risks, mechanisms, and therapeutic targets
Qu S, Zhou X, Zhang H. Genetics of IgA nephrology: risks, mechanisms, and therapeutic targets. Pediatric Nephrology 2024, 39: 3157-3165. PMID: 38600219, DOI: 10.1007/s00467-024-06369-7.Peer-Reviewed Original ResearchGenome-wide association studiesPopulation-based genome-wide association studiesComplex multifactorial traitsPolygenic risk scoresRisk lociAssociation studiesTherapeutic targetMultifactorial traitGenetic explorationGenetic researchGenetic causationMolecular mechanismsRisk scoreElevated serum Gd-IgA1 levelsIncreased riskPathogenesis modelGroup of individualsSerum Gd-IgA1 levelsGd-IgA1 levelsMedical treatmentLociGalactose-deficient IgA1RiskGeneticsGd-IgA1
2020
Idiopathic Membranous Nephropathy: Glomerular Pathological Pattern Caused by Extrarenal Immunity Activity
Liu W, Gao C, Liu Z, Dai H, Feng Z, Dong Z, Zheng Y, Gao Y, Tian X, Liu B. Idiopathic Membranous Nephropathy: Glomerular Pathological Pattern Caused by Extrarenal Immunity Activity. Frontiers In Immunology 2020, 11: 1846. PMID: 33042109, PMCID: PMC7524879, DOI: 10.3389/fimmu.2020.01846.BooksConceptsIdiopathic membranous nephropathyGlomerular lesionsThrombospondin type-1 domain-containing 7APathological patternsImmune complex depositionDevelopment of proteinuriaM-type receptorNeural epidermal growthSecretory phospholipase A2Glomerular basement membraneIgG4 predominanceProteinuria remissionCirculating AntibodiesClinical featuresGlomerular damageMembranous nephropathySpontaneous remissionAutoimmune responseComplex depositionExtrarenal tissuesImmune activityAutoimmunity initiationClinical practicePathogenesis modelTHSD7A antigen
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