Lactobacillus casei Cell Wall Extract and Production of Galactose-Deficient IgA1 in a Humanized IGHA1 Mouse Model
Li R, Wang M, Li J, Zhu L, Xie X, Wang H, Zhang X, Tian W, Zhang Y, Dong Y, Zan J, Li H, Zhang Y, Zhou X, Shi S, Shu C, Liu L, Jin J, Lv J, Zhang H. Lactobacillus casei Cell Wall Extract and Production of Galactose-Deficient IgA1 in a Humanized IGHA1 Mouse Model. Journal Of The American Society Of Nephrology 2024, 36: 60-72. PMID: 39172518, PMCID: PMC11706567, DOI: 10.1681/asn.0000000000000465.Peer-Reviewed Original ResearchLactobacillus casei cell wall extractAssociated with hematuriaGalactose-deficient IgA1Mouse modelIgA nephropathyWild-type C57BL/6J miceFactor H mutationCell wall extractsCFA-treated miceGd-IgA1 levelsElevated levelsGalactose-deficient IgA1 levelsIgA1-immune complexesModel of IgA nephropathyMouse chromosomal lociGlomerular mesangial areasMonths of ageTransgenic mouse modelHuman IgA1Hinge regionHuman IgA1 heavy chainMucosal sitesGd-IgA1Immune reactivityGlomerular alterationsHeterozygous mutations in factor H aggravate pathological damage in a stable IgA deposition model induced by Lactobacillus casei cell wall extract
Li J, Dong Y, Chen F, Yang H, Chen P, Li H, Shi S, Zhou X, Zhu L, Zhang Y, Liu L, Xie X, Yu F, Jin J, Lv J, Zhang H. Heterozygous mutations in factor H aggravate pathological damage in a stable IgA deposition model induced by Lactobacillus casei cell wall extract. Frontiers In Immunology 2024, 15: 1368322. PMID: 38558821, PMCID: PMC10978756, DOI: 10.3389/fimmu.2024.1368322.Peer-Reviewed Original ResearchCell wall extractsLactobacillus casei cell wall extractBiomarkers of kidney dysfunctionComplement activationFactor H mutationSeverity of glomerular lesionsPositive rate of IgAMild kidney damageDecline of kidney functionPathogenesis of IgA nephropathyProduction of IgA.Wall extractsGlomerular IgA depositionPathogenesis of IgANWild type controlsComplement overactivationElevated IgAElevated biomarkersHeterozygous mutationsC57BL/6 miceIgA-IgGKidney dysfunctionAlternative pathwayComplement inhibitorsIgA nephropathy
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