2012
Insulin-Like Growth Factors Promote Vasculogenesis in Embryonic Stem Cells
Piecewicz S, Pandey A, Roy B, Xiang S, Zetter B, Sengupta S. Insulin-Like Growth Factors Promote Vasculogenesis in Embryonic Stem Cells. PLOS ONE 2012, 7: e32191. PMID: 22363814, PMCID: PMC3283730, DOI: 10.1371/journal.pone.0032191.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell DifferentiationEmbryoid BodiesEmbryonic Stem CellsEndotheliumExtracellular Signal-Regulated MAP KinasesHypoxia-Inducible Factor 1, alpha SubunitInsulin-Like Growth Factor IInsulin-Like Growth Factor IIMesodermMiceModels, BiologicalNeovascularization, PhysiologicPodophyllotoxinProtein StabilityProto-Oncogene Proteins c-aktReceptor, IGF Type 1Receptor, IGF Type 2Signal TransductionVascular Endothelial Growth Factor AConceptsEmbryonic stem cellsStem cellsEndothelial differentiationInsulin-like growth factorStem cell-based modelsUp-regulation of VEGFIGF receptorsNeutralizing antibodiesFunctional blood vesselsPharmacological inhibitorsTherapeutic angiogenesisGrowth factorEndothelial cellsPromote vasculogenesisCell-based modelsCellular mechanismsGerm layersEmbryonic stemMesodermal lineagesEmbryoid body modelBlood vesselsEmbryoid bodiesVasculogenesisUp-regulatedTherapy
2008
Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
Schleicher M, Shepherd BR, Suarez Y, Fernandez-Hernando C, Yu J, Pan Y, Acevedo LM, Shadel GS, Sessa WC. Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. Journal Of Cell Biology 2008, 180: 101-112. PMID: 18195103, PMCID: PMC2213620, DOI: 10.1083/jcb.200706072.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaCells, CulturedCellular SenescenceCytoskeletonElectron Transport Complex IEndothelial CellsEndothelium, VascularHumansMiceMice, Inbred StrainsMitochondriaMitochondrial MembranesNeovascularization, PhysiologicNeuropeptidesPhosphatidylinositol 3-KinasesProhibitinsProto-Oncogene Proteins c-aktrac GTP-Binding Proteinsrac1 GTP-Binding ProteinReactive Oxygen SpeciesRepressor ProteinsSignal TransductionConceptsProhibitin 1Mitochondrial functionKnockdown of PHB1Inner mitochondrial membraneEndothelial cell motilityEndothelial cellsCytoskeletal rearrangementsMitochondrial membraneVivo angiogenesis assaysCell motilityAngiogenic capacityCellular senescenceReactive oxygen speciesMitochondrial productionFunctional blood vesselsImportant regulatorSenescenceAngiogenesis assayTube formationOxygen speciesVascular homeostasisCellsVascular systemRac1Yeast
2000
PR39, a peptide regulator of angiogenesis
Li J, Post M, Volk R, Gao Y, Li M, Metais C, Sato K, Tsai J, Aird W, Rosenberg R, Hampton T, Li J, Sellke F, Carmeliet P, Simons M. PR39, a peptide regulator of angiogenesis. Nature Medicine 2000, 6: 49-55. PMID: 10613823, DOI: 10.1038/71527.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimicrobial Cationic PeptidesAortaCapillariesCattleCell HypoxiaCells, CulturedCoronary VesselsCysteine EndopeptidasesDNA-Binding ProteinsEndothelium, VascularHeartHumansHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha SubunitIn Vitro TechniquesMacrophagesMiceMice, Inbred C57BLMice, TransgenicMultienzyme ComplexesMyocardial InfarctionMyocardial IschemiaNeovascularization, PhysiologicNuclear ProteinsPeptidesProteasome Endopeptidase ComplexRecombinant ProteinsSwineTranscription FactorsUbiquitinsUmbilical Veinsvon Willebrand FactorConceptsHypoxia-inducible factor-1α (HIF-1α) degradationMacrophage-derived peptideHypoxia-inducible factor-1α (HIF-1α) proteinCoronary flow studiesInflammation-induced angiogenesisInduction of angiogenesisMyocardial vasculatureTissue injuryPotent inductorFunctional blood vesselsBlood vesselsVascular structuresAngiogenesisSelective inhibitionPR39
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply