Insulin-Like Growth Factors Promote Vasculogenesis in Embryonic Stem Cells
Piecewicz S, Pandey A, Roy B, Xiang S, Zetter B, Sengupta S. Insulin-Like Growth Factors Promote Vasculogenesis in Embryonic Stem Cells. PLOS ONE 2012, 7: e32191. PMID: 22363814, PMCID: PMC3283730, DOI: 10.1371/journal.pone.0032191.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell DifferentiationEmbryoid BodiesEmbryonic Stem CellsEndotheliumExtracellular Signal-Regulated MAP KinasesHypoxia-Inducible Factor 1, alpha SubunitInsulin-Like Growth Factor IInsulin-Like Growth Factor IIMesodermMiceModels, BiologicalNeovascularization, PhysiologicPodophyllotoxinProtein StabilityProto-Oncogene Proteins c-aktReceptor, IGF Type 1Receptor, IGF Type 2Signal TransductionVascular Endothelial Growth Factor AConceptsEmbryonic stem cellsStem cellsEndothelial differentiationInsulin-like growth factorStem cell-based modelsUp-regulation of VEGFIGF receptorsNeutralizing antibodiesFunctional blood vesselsPharmacological inhibitorsTherapeutic angiogenesisGrowth factorEndothelial cellsPromote vasculogenesisCell-based modelsCellular mechanismsGerm layersEmbryonic stemMesodermal lineagesEmbryoid body modelBlood vesselsEmbryoid bodiesVasculogenesisUp-regulatedTherapy
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply