2023
β-catenin engages IKZF factors to control lymphopoiesis
Cosgun K, Jumaa H, Robinson M, Xu L, Xiao G, Arce D, Khanduja D, Chan L, Lee J, Schjerven H, Jellusova J, Müschen M. β-catenin engages IKZF factors to control lymphopoiesis. The Journal Of Immunology 2023, 210: 65.09-65.09. DOI: 10.4049/jimmunol.210.supp.65.09.Peer-Reviewed Original ResearchΒ-cateninZinc finger transcription factorFinger transcription factorDramatic nuclear accumulationGSK3β-dependent phosphorylationT cell signalingT cell developmentTCF factorsRepressive complexesTranscriptional controlEnhancer clusterInteractome studiesTranscriptional activationΒ-catenin activationCommon oncogenic driversInhibition of GSK3βTranscription factorsNegative regulationMesenchymal lineagesNuclear accumulationCell deathMYCT-lymphoid malignancyΒ-catenin expressionPromotes Proliferation
2021
Phosphoproteomic analysis of lung tissue from patients with pulmonary arterial hypertension
Sitapara R, Lam TT, Gandjeva A, Tuder RM, Zisman LS. Phosphoproteomic analysis of lung tissue from patients with pulmonary arterial hypertension. Pulmonary Circulation 2021, 11: 1-15. PMID: 34966541, PMCID: PMC8711668, DOI: 10.1177/20458940211031109.Peer-Reviewed Original ResearchCyclin-dependent kinase 1Pulmonary arterial hypertensionProtein kinasePhosphoproteomic analysisIdiopathic PAHKinase 1Zinc finger transcription factorLung tissueFinger transcription factorCGMP-dependent protein kinase 1Casein kinase 2Regulation of BclMass spectrometry-based analysisProtein kinase 1Arterial hypertensionImmune regulationImportant regulatory roleIdiopathic pulmonary arterial hypertensionRhoGTPase signalingGSK3 alphaKinase networkPhosphorylation assaysTranscription factorsBioinformatics analysisGSK3 beta
2015
Ikaros tumor suppressor function in pre-B ALL: potential role of Ikaros target gene Ctnnd1 (IRM10P.621)
Schjerven H, Eggesbo L, Lindeman I, Muschen M. Ikaros tumor suppressor function in pre-B ALL: potential role of Ikaros target gene Ctnnd1 (IRM10P.621). The Journal Of Immunology 2015, 194: 131.19-131.19. DOI: 10.4049/jimmunol.194.supp.131.19.Peer-Reviewed Original ResearchTumor suppressor functionTarget genesSuppressor functionDNA-binding zinc fingersTumor suppressorGenome-wide expression analysisHuman preZinc finger transcription factorFinger transcription factorIndirect target genesDownstream target genesB cell developmentImportant tumor suppressorRole of IkarosProper hematopoiesisZinc fingerChIP-seqRNA-seqTranscription factorsPatient-derived preExpression analysisPotential roleIkarosGenesIkaros expression
2009
Genome-Wide ChIP-Seq Reveals a Dramatic Shift in the EKLF Binding Profile Between Erythroid Progenitors and Erythroblasts.
Pilon A, Ajay S, Abaan H, Margulies E, Gallagher P, Bodine D. Genome-Wide ChIP-Seq Reveals a Dramatic Shift in the EKLF Binding Profile Between Erythroid Progenitors and Erythroblasts. Blood 2009, 114: 565. DOI: 10.1182/blood.v114.22.565.565.Peer-Reviewed Original ResearchTarget genesChIP-seqNearest geneSimultaneous genome-wide analysisC2H2 zinc finger transcription factorGenome-wide ChIP-seqErythroid Kruppel-like factorZinc finger transcription factorErythroid progenitorsTranscription factor occupancyBeta-globin locusGenome-wide analysisCell cycle control factorsProtein-DNA interactionsFinger transcription factorChIP-seq dataS-phase entryNon-repetitive regionsKruppel-like factorEKLF geneEKLF proteinFetal liverCell cycle S-phase entryChromatin remodelingFactor occupancy
2001
Physical interaction between p53 and primary response gene Egr-1.
Liu J, Grogan L, Nau MM, Allegra CJ, Chu E, Wright JJ. Physical interaction between p53 and primary response gene Egr-1. International Journal Of Oncology 2001, 18: 863-70. PMID: 11251186, DOI: 10.3892/ijo.18.4.863.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCell Culture TechniquesDNA-Binding ProteinsEarly Growth Response Protein 1Gene Expression RegulationGlutathione TransferaseHumansImmediate-Early ProteinsImmunoblottingMutationProtein BiosynthesisRecombinant ProteinsTranscription FactorsTumor Cells, CulturedTumor Suppressor Protein p53Zinc FingersConceptsPrimary response gene egr-1Egr-1 proteinEgr-1Gene Egr-1Transactivation regionTranscription factorsRegulatory proteinsZinc finger transcription factorComplex genetic programsZinc finger motifsZinc finger domainFinger transcription factorProtein-protein interactionsSignal transduction pathwaysTumor suppressor p53Nuclear transcription factorFinger motifTranscriptional controlFinger domainGenetic programTransduction pathwaysConstitutive overexpressionRecombinant p53Respective proteinsPhysical association
1999
GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease
Pehlivan T, Pober B, Brueckner M, Garrett S, Slaugh R, Van Rheeden R, Wilson D, Watson M, Hing A. GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease. American Journal Of Medical Genetics 1999, 83: 201-206. PMID: 10096597, DOI: 10.1002/(sici)1096-8628(19990319)83:3<201::aid-ajmg11>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsCardiac transcription factor genesZinc finger transcription factorHuman chromosome armsTranscription factor genesFinger transcription factorCardiac gene expressionChromosome armsTranscription factorsFactor genesGene expressionGATA4 geneInterstitial deletionGATA-4GenesLociFISH analysisSitu hybridizationDeletionHaploinsufficiencySubmicroscopic deletionRecent studiesPhenotype of patientsCellsMonosomyNormal karyotype
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