2001
Physical interaction between p53 and primary response gene Egr-1.
Liu J, Grogan L, Nau MM, Allegra CJ, Chu E, Wright JJ. Physical interaction between p53 and primary response gene Egr-1. International Journal Of Oncology 2001, 18: 863-70. PMID: 11251186, DOI: 10.3892/ijo.18.4.863.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCell Culture TechniquesDNA-Binding ProteinsEarly Growth Response Protein 1Gene Expression RegulationGlutathione TransferaseHumansImmediate-Early ProteinsImmunoblottingMutationProtein BiosynthesisRecombinant ProteinsTranscription FactorsTumor Cells, CulturedTumor Suppressor Protein p53Zinc FingersConceptsPrimary response gene egr-1Egr-1 proteinEgr-1Gene Egr-1Transactivation regionTranscription factorsRegulatory proteinsZinc finger transcription factorComplex genetic programsZinc finger motifsZinc finger domainFinger transcription factorProtein-protein interactionsSignal transduction pathwaysTumor suppressor p53Nuclear transcription factorFinger motifTranscriptional controlFinger domainGenetic programTransduction pathwaysConstitutive overexpressionRecombinant p53Respective proteinsPhysical association
1996
Insulin-induced egr-1 and c-fos Expression in 32D Cells Requires Insulin Receptor, Shc, and Mitogen-activated Protein Kinase, but Not Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase Activation*
Harada S, Smith R, Smith J, White M, Jarett L. Insulin-induced egr-1 and c-fos Expression in 32D Cells Requires Insulin Receptor, Shc, and Mitogen-activated Protein Kinase, but Not Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase Activation*. Journal Of Biological Chemistry 1996, 271: 30222-30226. PMID: 8939974, DOI: 10.1074/jbc.271.47.30222.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCell LineCHO CellsCricetinaeDNA-Binding ProteinsEarly Growth Response Protein 1Enzyme ActivationEnzyme InhibitorsGene Expression RegulationGRB2 Adaptor ProteinImmediate-Early ProteinsInsulinInsulin Receptor Substrate ProteinsMicePhosphatidylinositol 3-KinasesPhosphoproteinsPhosphorylationPhosphotransferases (Alcohol Group Acceptor)Protein KinasesProteinsProto-Oncogene Proteins c-fosReceptor, InsulinRNA, MessengerTranscription FactorsTyrosineConceptsC-fos expressionInsulin receptor substrate-1Egr-1 expressionInsulin receptorReceptor substrate-1Mitogen-activated protein kinase activationEgr-1Protein kinase activationMultiple signal transduction pathwaysBlot analysisEffect of insulinSignal transduction pathwaysSubstrate-1Tyrosine phosphorylationImmediate early gene Egr-1Mitogen-activated protein kinase kinase inhibitorWestern blot analysisProtein kinase kinase inhibitorInsulin receptor tyrosine phosphorylationInsulin treatmentKinase activationIRS-1 phosphorylationTransduction pathwaysKinase kinase inhibitorGene Egr-1
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