2005
Polycystin-2 Regulates Proliferation and Branching Morphogenesis in Kidney Epithelial Cells*
Grimm DH, Karihaloo A, Cai Y, Somlo S, Cantley LG, Caplan MJ. Polycystin-2 Regulates Proliferation and Branching Morphogenesis in Kidney Epithelial Cells*. Journal Of Biological Chemistry 2005, 281: 137-144. PMID: 16278216, DOI: 10.1074/jbc.m507845200.Peer-Reviewed Original ResearchConceptsPolycystin-2Kidney epithelial cellsPolycystin-1Cell proliferationRegulation of tubulogenesisWild-type proteinMultiple fluid-filled cystsAutosomal dominant polycystic kidney diseaseTubule formationEpithelial cellsExtracellular-related kinaseRegulatory machineryPolycystin proteinsBranching morphogenesisNegative regulatorRespective proteinsGenes PKD1Regulates ProliferationChannel mutantsMorphogenesisFluid-filled cystsCell growthProper growthChannel activityProtein
2001
Physical interaction between p53 and primary response gene Egr-1.
Liu J, Grogan L, Nau MM, Allegra CJ, Chu E, Wright JJ. Physical interaction between p53 and primary response gene Egr-1. International Journal Of Oncology 2001, 18: 863-70. PMID: 11251186, DOI: 10.3892/ijo.18.4.863.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCell Culture TechniquesDNA-Binding ProteinsEarly Growth Response Protein 1Gene Expression RegulationGlutathione TransferaseHumansImmediate-Early ProteinsImmunoblottingMutationProtein BiosynthesisRecombinant ProteinsTranscription FactorsTumor Cells, CulturedTumor Suppressor Protein p53Zinc FingersConceptsPrimary response gene egr-1Egr-1 proteinEgr-1Gene Egr-1Transactivation regionTranscription factorsRegulatory proteinsZinc finger transcription factorComplex genetic programsZinc finger motifsZinc finger domainFinger transcription factorProtein-protein interactionsSignal transduction pathwaysTumor suppressor p53Nuclear transcription factorFinger motifTranscriptional controlFinger domainGenetic programTransduction pathwaysConstitutive overexpressionRecombinant p53Respective proteinsPhysical association
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply