2024
Akt is a mediator of artery specification during zebrafish development
Zhou W, Ghersi J, Ristori E, Semanchik N, Prendergast A, Zhang R, Carneiro P, Baldissera G, Sessa W, Nicoli S. Akt is a mediator of artery specification during zebrafish development. Development 2024, 151: dev202727. PMID: 39101673, PMCID: PMC11441982, DOI: 10.1242/dev.202727.Peer-Reviewed Original ResearchArterial specificationEndothelial cellsVascular endothelial growth factor ADorsal aortaEndothelial growth factor ASingle-cell RNA sequencing analysisGrowth factor AArtery endothelial cellsEmbryonic cardiovascular systemConstitutively active Akt1Ligand-independent activationActivation of NotchArteriovenous malformationsCongenital malformationsRNA sequencing analysisVEGF-AProtein kinase BUpstream of NotchSequence analysisCardiovascular developmentSpecific expressionAkt kinaseActive Akt1Zebrafish developmentCardiovascular system
2023
Hepatocellular carcinoma cell-derived small extracellular vesicle-associated CD147 serves as a diagnostic marker and promotes endothelial cell angiogenesis via the PI3K/Akt pathway
Huang D, Zhang W, Chen J, Jiao Z, Wang X, Rao D, Li W, Hu D, Xie F, Wang X, Li Z, Yi X, Wu J, Jiang Y, Wang Q, Zhong T. Hepatocellular carcinoma cell-derived small extracellular vesicle-associated CD147 serves as a diagnostic marker and promotes endothelial cell angiogenesis via the PI3K/Akt pathway. Extracellular Vesicles And Circulating Nucleic Acids 2023, 4: 532-547. PMID: 40357132, PMCID: PMC12066417, DOI: 10.20517/evcna.2023.30.Peer-Reviewed Original ResearchVascular endothelial growth factor AHepatocellular carcinomaHealthy donorsSmall extracellular vesiclesNano-flow cytometerEndothelial cell angiogenesisDiagnostic markerLiver cirrhosisPI3K/Akt pathwayCD147 expressionMatrigel plug angiogenesis assayPlasma of HCC patientsPromote angiogenesisHepatocellular carcinoma patientsCell angiogenesisEndothelial growth factor AExtracellular vesiclesGrowth factor AScratch wound healing assayHuman umbilical vein endothelial cellsProcess of HCC developmentHepatocellular carcinoma tissue samplesUmbilical vein endothelial cellsWound healing assayCell proliferation assay
2017
Epithelial membrane protein-2 (EMP2) promotes angiogenesis in glioblastoma multiforme
Qin Y, Takahashi M, Sheets K, Soto H, Tsui J, Pelargos P, Antonios J, Kasahara N, Yang I, Prins R, Braun J, Gordon L, Wadehra M. Epithelial membrane protein-2 (EMP2) promotes angiogenesis in glioblastoma multiforme. Journal Of Neuro-Oncology 2017, 134: 29-40. PMID: 28597184, PMCID: PMC5695892, DOI: 10.1007/s11060-017-2507-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD34Cell Line, TumorCell MovementFemaleGene Expression Regulation, NeoplasticGlioblastomaGreen Fluorescent ProteinsHuman Umbilical Vein Endothelial CellsHumansImmunoglobulin GMembrane GlycoproteinsMiceMice, NudeMicroarray AnalysisNeovascularization, PathologicRNA, Small InterferingTransfectionVascular Endothelial Growth Factor AXenograft Model Antitumor AssaysConceptsExpression of epithelial membrane protein-2Anti-angiogenic therapyEpithelial membrane protein-2Glioblastoma multiformeSurvival benefitAnti-vascular endothelial growth factor AProgression-free survival benefitReduction of tumor loadDecreased tumor vasculatureRecurrent glioblastoma multiformeVEGF-A levelsEndothelial growth factor AAbnormal blood vesselsProtein 2Malignant brain tumorsAggressive malignant brain tumorGrowth factor AHuman glioblastoma multiformePotential therapeutic effectsTumor loadTumor expressionPro-angiogenic effectsTumor vasculatureClinical prognosisVEGF-AProangiogenic Function of T Cells in Corneal Transplantation
Di Zazzo A, Tahvildari M, Subbarayal B, Yin J, Dohlman T, Inomata T, Mashaghi A, Chauhan S, Dana R. Proangiogenic Function of T Cells in Corneal Transplantation. Transplantation 2017, 101: 778-785. PMID: 27490416, PMCID: PMC5290298, DOI: 10.1097/tp.0000000000001390.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCell LineCell ProliferationCoculture TechniquesCorneaCorneal NeovascularizationCorneal TransplantationDisease Models, AnimalEndothelial CellsInterferon-gammaMaleMice, Inbred BALB CMice, Inbred C57BLNeovascularization, PathologicSignal TransductionTransplantation, HomologousTransplantation, IsogeneicVascular Endothelial Growth Factor AVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-2ConceptsVascular endothelial cellsAllogeneic T cellsDraining Lymph NodesVEGF-A protein expressionT cellsVEGF-AVEGF-R2High riskLymph nodesProtein expressionVEC proliferationT cell-mediated allograft rejectionConventional effector T cellsExpression of vascular endothelial growth factor (VEGF)-ALow riskFunction of T cellsVascular endothelial growth factor (VEGF)-AEffector T cellsCD4 T cellsMessenger RNAVascular endothelial growth factor AVEGF-R2 mRNA expressionEndothelial growth factor ABlocking VEGF-AVEGF receptor 2
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