Proangiogenic Function of T Cells in Corneal Transplantation
Di Zazzo A, Tahvildari M, Subbarayal B, Yin J, Dohlman T, Inomata T, Mashaghi A, Chauhan S, Dana R. Proangiogenic Function of T Cells in Corneal Transplantation. Transplantation 2017, 101: 778-785. PMID: 27490416, PMCID: PMC5290298, DOI: 10.1097/tp.0000000000001390.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCell LineCell ProliferationCoculture TechniquesCorneaCorneal NeovascularizationCorneal TransplantationDisease Models, AnimalEndothelial CellsInterferon-gammaMaleMice, Inbred BALB CMice, Inbred C57BLNeovascularization, PathologicSignal TransductionTransplantation, HomologousTransplantation, IsogeneicVascular Endothelial Growth Factor AVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-2ConceptsVascular endothelial cellsAllogeneic T cellsDraining Lymph NodesVEGF-A protein expressionT cellsVEGF-AVEGF-R2High riskLymph nodesProtein expressionVEC proliferationT cell-mediated allograft rejectionConventional effector T cellsExpression of vascular endothelial growth factor (VEGF)-ALow riskFunction of T cellsVascular endothelial growth factor (VEGF)-AEffector T cellsCD4 T cellsMessenger RNAVascular endothelial growth factor AVEGF-R2 mRNA expressionEndothelial growth factor ABlocking VEGF-AVEGF receptor 2
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