2010
Regulation of CD1 Antigen-presenting Complex Stability*
Odyniec A, Barral D, Garg S, Tatituri R, Besra G, Brenner M. Regulation of CD1 Antigen-presenting Complex Stability*. Journal Of Biological Chemistry 2010, 285: 11937-11947. PMID: 20133943, PMCID: PMC2852931, DOI: 10.1074/jbc.m109.077933.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigens, CD1beta 2-MicroglobulinCell LineCell MembraneEndosomesHeLa CellsHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansHydrogen-Ion ConcentrationLysosomesMiceMultiprotein ComplexesProtein IsoformsProtein StabilityRecombinant ProteinsTransfectionConceptsCD1 heavy chainsCell surfaceHeavy chainEndosomal pHQuality control mechanismsCD1 proteinsCell surface pHCD1 isoformsLipid antigensAcidic endosomal pHAntigen-loading complexesPH optimaAcidic pHIntracellular compartmentsMildly acidic pHLipid exchangeAntigen bindingNeutral pHTraffickingPeptide antigensCellsBindingCD1LipidBeta(2)-microglobulin
2007
Expression of the Voltage-Gated Sodium Channel NaV1.5 in the Macrophage Late Endosome Regulates Endosomal Acidification
Carrithers MD, Dib-Hajj S, Carrithers LM, Tokmoulina G, Pypaert M, Jonas EA, Waxman SG. Expression of the Voltage-Gated Sodium Channel NaV1.5 in the Macrophage Late Endosome Regulates Endosomal Acidification. The Journal Of Immunology 2007, 178: 7822-7832. PMID: 17548620, DOI: 10.4049/jimmunol.178.12.7822.Peer-Reviewed Original ResearchConceptsVoltage-gated sodium channelsEndosomal acidificationLate endosomesPlasma membraneDistinct subcellular localizationPrimary human monocyte-derived macrophagesSodium channelsHuman monocyte-derived macrophagesSubcellular localizationSodium channel Nav1.5Human monocytic cell lineMonocyte-derived macrophagesMonocytic cell lineCardiac voltage-gated sodium channelNovel mechanismCell linesEndosomesMembrane potentialChannel Nav1.5Endosomal pHTHP-1Neuronal channelsMacrophage functionMembraneAcidification
1999
Recombinant Vesicular Stomatitis Virus Expressing Respiratory Syncytial Virus (RSV) Glycoproteins: RSV Fusion Protein Can Mediate Infection and Cell Fusion
Kahn J, Schnell M, Buonocore L, Rose J. Recombinant Vesicular Stomatitis Virus Expressing Respiratory Syncytial Virus (RSV) Glycoproteins: RSV Fusion Protein Can Mediate Infection and Cell Fusion. Virology 1999, 254: 81-91. PMID: 9927576, DOI: 10.1006/viro.1998.9535.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBinding SitesCell LineCricetinaeCytoplasmGene ExpressionGenetic VectorsGlycoproteinsHN ProteinHumansMembrane FusionMolecular Sequence DataRecombinant Fusion ProteinsRespiratory Syncytial Virus, HumanTumor Cells, CulturedVesicular stomatitis Indiana virusViral Envelope ProteinsViral Fusion ProteinsViral ProteinsVirionConceptsRecombinant vesicular stomatitis virusVesicular stomatitis virusRSV fusion proteinRSV F glycoproteinRSV vaccineF recombinantsRSV glycoproteinsRSV proteinsEnvelope glycoproteinVirus attachmentFusion (F) envelope glycoproteinsF glycoproteinG glycoproteinStomatitis virusLarge syncytiaGlycoproteinPH-independent pathwayCell surfaceCell fusionCytoplasmic tail sequencesVSV G.Endosomal pHFusion activityVaccineFusion protein
1985
Effects of monovalent cations on Semliki Forest virus entry into BHK-21 cells.
Helenius A, Kielian M, Wellsteed J, Mellman I, Rudnick G. Effects of monovalent cations on Semliki Forest virus entry into BHK-21 cells. Journal Of Biological Chemistry 1985, 260: 5691-5697. PMID: 3988769, DOI: 10.1016/s0021-9258(18)89078-0.Peer-Reviewed Original ResearchConceptsSemliki Forest virusEndosome membraneViral envelopeBaby hamster kidney cellsMammalian cellsEndosomal membranesLow endosomalBHK-21 cellsHamster kidney cellsVirus endocytosisIntact cellsConformational changesEndosomesPrelysosomal endosomesViral spike glycoproteinVirus fusionKidney cellsAcidic endosomal pHViral RNAVoltage-sensitive probeEndocytosisVirus entryEndosomal pHCellsSpike glycoprotein
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