2010
Regulation of CD1 Antigen-presenting Complex Stability*
Odyniec A, Barral D, Garg S, Tatituri R, Besra G, Brenner M. Regulation of CD1 Antigen-presenting Complex Stability*. Journal Of Biological Chemistry 2010, 285: 11937-11947. PMID: 20133943, PMCID: PMC2852931, DOI: 10.1074/jbc.m109.077933.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigens, CD1beta 2-MicroglobulinCell LineCell MembraneEndosomesHeLa CellsHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansHydrogen-Ion ConcentrationLysosomesMiceMultiprotein ComplexesProtein IsoformsProtein StabilityRecombinant ProteinsTransfectionConceptsCD1 heavy chainsCell surfaceHeavy chainEndosomal pHQuality control mechanismsCD1 proteinsCell surface pHCD1 isoformsLipid antigensAcidic endosomal pHAntigen-loading complexesPH optimaAcidic pHIntracellular compartmentsMildly acidic pHLipid exchangeAntigen bindingNeutral pHTraffickingPeptide antigensCellsBindingCD1LipidBeta(2)-microglobulin
2009
Chapter 1 Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity
Cohen N, Garg S, Brenner M. Chapter 1 Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity. Advances In Immunology 2009, 102: 1-94. PMID: 19477319, DOI: 10.1016/s0065-2776(09)01201-2.Peer-Reviewed Original ResearchConceptsInvariant natural killer TInvariant natural killer T cellsCD1d-restricted T cellsLipid antigensT cell receptorT cellsSemi-invariant T cell receptorBinding lipid antigensCD1-restricted T cellsCell surfaceActivate iNKT cellsRange of pathogensGammadelta T-cell receptorT cell-deficient miceImmune responseNatural killer TCD1 familyCD1 isoformsT cell subsetsContext of microbial infectionEndocytic compartmentsClearance of pathogensINKT cellsCD1 moleculesCell-mediated immunity
2008
CD1a and MHC Class I Follow a Similar Endocytic Recycling Pathway
Barral D, Cavallari M, McCormick P, Garg S, Magee A, Bonifacino J, De Libero G, Brenner M. CD1a and MHC Class I Follow a Similar Endocytic Recycling Pathway. Traffic 2008, 9: 1446-1457. PMID: 18564371, PMCID: PMC3839101, DOI: 10.1111/j.1600-0854.2008.00781.x.Peer-Reviewed Original ResearchMeSH KeywordsADP-Ribosylation Factor 6ADP-Ribosylation FactorsAnimalsAntigen PresentationAntigens, CD1ClathrinCytoplasmDendritic CellsEndocytosisEndosomesHeLa CellsHistocompatibility Antigens Class IHumansLeukocytes, MononuclearMembrane MicrodomainsMutationProtein Modification, TranslationalProtein SubunitsProtein Transportrab GTP-Binding ProteinsT-LymphocytesTransfectionConceptsDetergent-resistant membrane microdomainsRecycling pathwayCytoplasmic tailSorting motifCD1 isoformsMajor histocompatibility complexTyrosine-based sorting motifHuman CD1 isoformsIndependent of clathrinEndocytic recycling pathwayPathway of internalizationInternalization of proteinsClathrin-mediated pathwayMode of internalizationDynamin-independentCD1 proteinsS-acylationRate of internalizationFamilies of major histocompatibility complexPosttranslational modificationsMembrane microdomainsClathrinAntigen loading compartmentsMajor histocompatibility complex class IProtein
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