2025
Functional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia
Song Y, Zhu H, Wu Z, Hu W, Zhang S, Zhou Y, Peng Y, Yang Y, Li W, Shi H, Yang G, Zhang Y, Lv L. Functional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia. European Child & Adolescent Psychiatry 2025, 34: 2463-2472. PMID: 39928122, DOI: 10.1007/s00787-025-02656-2.Peer-Reviewed Original ResearchPrefrontal-thalamic-cerebellar circuitMedial prefrontal cortexMiddle temporal gyrusPosterior cerebellar lobeFunctional connectivityReduced FCTemporal gyrusResting-state functional magnetic resonance imaging scansFunctional magnetic resonance imaging scansLeft medial prefrontal cortexEarly stages of schizophreniaCerebellar lobeRight middle temporal gyrusHealthy controlsPositive symptom scoresFirst-episode schizophreniaVisuospatial Memory TestStages of schizophreniaFunctional connectivity changesRight posterior cerebellar lobePrefrontal cortexMemory testLeft precuneusFC abnormalitiesBrain regions
2024
Short-term antipsychotic treatment reduces functional connectivity of the striatum in first-episode drug-naïve early-onset schizophrenia
Hu W, Ran X, Wu Z, Zhu H, Kou Y, Zhang S, Yang G, Li W, Yang Y, Lv L, Zhang Y. Short-term antipsychotic treatment reduces functional connectivity of the striatum in first-episode drug-naïve early-onset schizophrenia. Schizophrenia Research 2024, 270: 281-288. PMID: 38944974, DOI: 10.1016/j.schres.2024.06.016.Peer-Reviewed Original ResearchPositive and Negative Syndrome ScaleEarly-onset schizophreniaEarly-onset schizophrenia patientsDorsal caudal putamenStriatal FCFunctional connectivityAntipsychotic treatmentStriatal subregionsFrontal gyrusPositive and Negative Syndrome Scale negative scoresResting-state functional magnetic resonance imaging scansShort-term antipsychotic treatmentFunctional magnetic resonance imaging scansWeeks of treatmentEarly stages of schizophreniaHealthy controlsLeft supplementary motor areaNegative Syndrome ScaleInferior frontal gyrusStages of schizophreniaMiddle frontal gyrusInferior parietal lobuleMeasure psychiatric symptomsAbnormal functional connectivityRight postcentral gyrusAbnormal regional homogeneity as a potential imaging indicator for identifying adolescent-onset schizophrenia: Insights from resting-state functional magnetic resonance imaging
Zhou Y, Zhu H, Hu W, Song Y, Zhang S, Peng Y, Yang G, Shi H, Yang Y, Li W, Lv L, Zhang Y. Abnormal regional homogeneity as a potential imaging indicator for identifying adolescent-onset schizophrenia: Insights from resting-state functional magnetic resonance imaging. Asian Journal Of Psychiatry 2024, 98: 104106. PMID: 38865883, DOI: 10.1016/j.ajp.2024.104106.Peer-Reviewed Original ResearchAdolescent-onset schizophreniaReHo valuesRegional homogeneityAdolescent-onset schizophrenia patientsResting-state functional magnetic resonance imaging scansFunctional magnetic resonance imaging scansRight middle frontal gyrusResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingEducation-matched controlsMiddle frontal gyrusLeft precentral gyrusAbnormal regional homogeneityAO patientsFunctional magnetic resonanceLeft inferior parietalPANSS scoresMagnetic resonance imaging scansSchizophrenia patientsFrontal gyrusAngular gyriReHo abnormalitiesInferior parietalPrecentral gyrusReHo method
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