2018
Methods to Probe Calcium Regulation by BCL-2 Family Members
Carpio MA, Katz SG. Methods to Probe Calcium Regulation by BCL-2 Family Members. Methods In Molecular Biology 2018, 1877: 173-183. PMID: 30536006, DOI: 10.1007/978-1-4939-8861-7_12.Peer-Reviewed Original ResearchConceptsMitochondrial outer membrane permeabilizationBcl-2 family membersEndoplasmic reticulumOuter membrane permeabilizationProcess of apoptosisSuch important functionsMembrane permeabilizationDirect regulationFamily membersAdditional roleImportant functionsCalcium regulationApoptosisRegulationRelease of calciumMitochondriaPermeabilizationBiologyCytosolMembersReticulum
2012
microRNA Regulatory Network Inference Identifies miR-34a as a Novel Regulator of TGF-β Signaling in Glioblastoma
Genovese G, Ergun A, Shukla SA, Campos B, Hanna J, Ghosh P, Quayle SN, Rai K, Colla S, Ying H, Wu CJ, Sarkar S, Xiao Y, Zhang J, Zhang H, Kwong L, Dunn K, Wiedemeyer WR, Brennan C, Zheng H, Rimm DL, Collins JJ, Chin L. microRNA Regulatory Network Inference Identifies miR-34a as a Novel Regulator of TGF-β Signaling in Glioblastoma. Cancer Discovery 2012, 2: 736-749. PMID: 22750848, PMCID: PMC3911772, DOI: 10.1158/2159-8290.cd-12-0111.Peer-Reviewed Original ResearchConceptsMultidimensional cancer genomic dataPromoter enrichment analysisCancer genomic dataNovel regulatorGenomic dataContext likelihoodEnrichment analysisPutative regulatory networksFunctional genetic screensDifferent genetic elementsGenetic screenTGF-β signalingTranscriptional networksPlatelet-derived growth factorMRNA nodesGenome spaceRegulatory networksTranscriptomic networksBiology of cancerNovel regulationGenetic elementsTumor suppressorSilico analysisDirect regulationNew pathogenetic insights
2005
Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells.
Du H, Daftary GS, Lalwani SI, Taylor HS. Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Endocrinology 2005, 19: 2222-33. PMID: 15905361, DOI: 10.1210/me.2004-0336.Peer-Reviewed Original ResearchMeSH KeywordsBase PairingCalcitriolCell LineDNA-Binding ProteinsEndometriumFemaleGene Expression RegulationGenes, ReporterHomeobox A10 ProteinsHomeodomain ProteinsHumansLuciferasesMolecular Sequence DataMyeloid CellsPromoter Regions, GeneticReceptors, CalcitriolRNA, MessengerStromal CellsTranscription, GeneticU937 CellsUp-RegulationVitamin D Response ElementConceptsHuman endometrial stromal cell lineVitamin D response elementVitamin D receptorEndometrial stromal cellsHuman endometrial stromal cellsPutative vitamin D response elementsStromal cellsVitamin DPrimary endometrial stromal cellsEndometrial stromal cell linePrimary human endometrial stromal cellsDirect regulationMyeloid leukemic cell differentiationUpstream regulatory sequencesUterine stromal cellsReporter gene expressionCell linesPrimary stromal cellsRegulation of HOXA10Stromal cell lineD response elementHuman myelomonocytic cellsLuciferase reporter constructsLeukemic cell differentiationHuman myelomonocytic cell line
2004
Gastric parietal cell acid secretion in mice can be regulated independently of H+/K+ ATPase endocytosis
Nguyen NV, Gleeson PA, Courtois-Coutry N, Caplan MJ, van Driel IR. Gastric parietal cell acid secretion in mice can be regulated independently of H+/K+ ATPase endocytosis. Gastroenterology 2004, 127: 145-154. PMID: 15236181, DOI: 10.1053/j.gastro.2004.04.016.Peer-Reviewed Original ResearchConceptsApical plasma membranePlasma membraneIntracellular traffickingTyrosine-based endocytosis motifATPase activityATPase beta subunitMembrane traffickingATPase endocytosisTrafficking eventsEndocytosis motifParietal cell ultrastructureTubulovesicular compartmentCytoplasmic tailIntracytoplasmic compartmentCl- conductanceParietal cell acid secretionBeta subunitParietal cellsDirect regulationProton pumpCell ultrastructureTraffickingATPaseCellsRegulation
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