2024
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy
Witten J, Raji I, Manan R, Beyer E, Bartlett S, Tang Y, Ebadi M, Lei J, Nguyen D, Oladimeji F, Jiang A, MacDonald E, Hu Y, Mughal H, Self A, Collins E, Yan Z, Engelhardt J, Langer R, Anderson D. Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy. Nature Biotechnology 2024, 1-10. PMID: 39658727, PMCID: PMC12149338, DOI: 10.1038/s41587-024-02490-y.Peer-Reviewed Original ResearchLipid nanoparticlesMRNA deliveryIonizable lipidsImprove nanoparticle deliveryPulmonary gene therapyDelivery in vitroNucleic acid deliveryNeural networkGene therapyNasal mucosaNanoparticle deliveryMouse lungFerret lungsAcid deliveryMouse muscleMessage-passing neural networkDelivery technologiesIn vivoLipid designLungMiceDeliveryDeep learningMRNALipidA Minimalist Pathogen‐Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy
Miao Y, Niu L, Lv X, Zhang Q, Xiao Z, Ji Z, Chen L, Liu Y, Liu N, Zhu J, Yang Y, Chen Q. A Minimalist Pathogen‐Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy. Advanced Materials 2024, 36: e2410715. PMID: 39210649, DOI: 10.1002/adma.202410715.Peer-Reviewed Original ResearchCancer immunotherapyMaturation of antigen-presenting cellsVaccine carriersImmune checkpoint blockade therapyAntigen-specific immune responsesInhibition of tumor growthCheckpoint blockade therapyEnhanced cancer immunotherapyAntigen-presenting cellsVaccine delivery technologiesB16-OVABlockade therapyImmune activationTumor modelTumor growthAntigen loadNanovaccineImmune responseMeticulous screeningAntigenic peptidesImmunostimulatory characteristicsChain ratioDelivery technologiesImmunotherapyIn vivo
2022
Consensus Recommendations for the Use of Automated Insulin Delivery Technologies in Clinical Practice
Phillip M, Nimri R, Bergenstal RM, Barnard-Kelly K, Danne T, Hovorka R, Kovatchev BP, Messer LH, Parkin CG, Ambler-Osborn L, Amiel SA, Bally L, Beck RW, Biester S, Biester T, Blanchette JE, Bosi E, Boughton CK, Breton MD, Brown SA, Buckingham BA, Cai A, Carlson AL, Castle JR, Choudhary P, Close KL, Cobelli C, Criego AB, Davis E, de Beaufort C, de Bock MI, DeSalvo DJ, DeVries JH, Dovc K, Doyle FJ, Ekhlaspour L, Shvalb NF, Forlenza GP, Gallen G, Garg SK, Gershenoff DC, Gonder-Frederick LA, Haidar A, Hartnell S, Heinemann L, Heller S, Hirsch IB, Hood KK, Isaacs D, Klonoff DC, Kordonouri O, Kowalski A, Laffel L, Lawton J, Lal RA, Leelarathna L, Maahs DM, Murphy HR, Nørgaard K, O’Neal D, Oser S, Oser T, Renard E, Riddell MC, Rodbard D, Russell SJ, Schatz DA, Shah VN, Sherr JL, Simonson GD, Wadwa RP, Ward C, Weinzimer SA, Wilmot EG, Battelino T. Consensus Recommendations for the Use of Automated Insulin Delivery Technologies in Clinical Practice. Endocrine Reviews 2022, 44: 254-280. PMID: 36066457, PMCID: PMC9985411, DOI: 10.1210/endrev/bnac022.Peer-Reviewed Original ResearchConceptsInsulin delivery technologiesGlycemic goalsNear-normal glucose levelsLong-term complicationsReal-world studyHypoglycemia riskDiabetes QualityConsensus recommendationsGlucose levelsGlobal prevalenceDiabetes managementEligibility criteriaClinical practiceDelivery technologiesHealthcare providersClinical settingDiabetesInsurance coverageSignificant proportionCliniciansAid successPWDPayersComplicationsTremendous advances
2017
Treatment Delivery Technology for Brachytherapy
Cunha J, Han D. Treatment Delivery Technology for Brachytherapy. 2017, 41-67. DOI: 10.1007/978-3-319-44827-5_3.Chapters
2011
Visualization of plasmid delivery to keratinocytes in mouse and human epidermis
González-González E, Kim YC, Speaker TJ, Hickerson RP, Spitler R, Birchall JC, Lara MF, Hu RH, Liang Y, Kirkiles-Smith N, Prausnitz MR, Milstone LM, Contag CH, Kaspar RL. Visualization of plasmid delivery to keratinocytes in mouse and human epidermis. Scientific Reports 2011, 1: 158. PMID: 22355673, PMCID: PMC3240989, DOI: 10.1038/srep00158.Peer-Reviewed Original ResearchConceptsIdeal target organHuman skin xenograftsAccessibility of skinSkin delivery technologiesNon-invasive intravital imagingIntradermal injectionSkin xenograftsClinical utilityTarget organsPatient-friendly deliveryMouse skinBioluminescence imagingSkin model systemIntravital imagingNoninvasive assayTransfection of cellsIntravital fluorescenceHuman epidermisIndividual keratinocytesKeratinocytesSkinNucleic acid-based therapeuticsMiceReporter plasmidDelivery technologies
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