2023
The imPAct of Trimetazidine on MicrOcirculation after Stenting for stable coronary artery disease (PATMOS study)
Ilic I, Timcic S, Milosevic M, Boskovic S, Odanovic N, Furtula M, Dobric M, Aleksandric S, Otasevic P. The imPAct of Trimetazidine on MicrOcirculation after Stenting for stable coronary artery disease (PATMOS study). Frontiers In Cardiovascular Medicine 2023, 10: 1112198. PMID: 37456821, PMCID: PMC10348888, DOI: 10.3389/fcvm.2023.1112198.Peer-Reviewed Original ResearchIndex of microcirculatory resistanceIndex of microcirculatory resistance valuesPercutaneous coronary interventionFractional flow reserveCoronary flow reserveElective percutaneous coronary interventionFractional flow reserve valuesEffect of trimetazidineStandard therapyPrior to elective percutaneous coronary interventionTrimetazidine groupMicrocirculatory resistanceFlow reserveCompared to standard therapyStable coronary artery diseaseProtective effect of trimetazidineEpicardial coronary artery stenosisCoronary artery diseaseCoronary artery lesionsNative coronary artery lesionsCoronary artery stenosisImpact of trimetazidinePromotes glucose oxidationReduced myocardial injuryRisk profile
2022
Shortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis
Park DY, Wang P, An S, Grimshaw AA, Frampton J, Ohman EM, Rao SV, Nanna MG. Shortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis. American Heart Journal 2022, 251: 101-114. PMID: 35654162, PMCID: PMC10904033, DOI: 10.1016/j.ahj.2022.05.019.Peer-Reviewed Original ResearchConceptsMonths of DAPTHazard ratioIschemic eventsDuration of DAPTSelect patient characteristicsDual antiplatelet therapyAcute coronary syndromeCoronary artery lesionsPercutaneous coronary interventionConfidence intervalsAssociation of outcomesRandom-effects modelComprehensive literature searchMeta-regression analysisMajor bleedingAntiplatelet therapyCoronary syndromeArtery lesionsCoronary interventionControlled TrialsPatient characteristicsPrespecified outcomesGreater proportionSimilar efficacySystematic review
2019
First-in-Human Study of Paclitaxel Drug-Coated Chocolate Coronary Percutaneous Transluminal Coronary Angioplasty Balloon Catheter in De Novo Coronary Artery Lesions
Garcia-Lithgow C, Tirziu D, Zhou S, Bouras G, Shah T, Grubman D, Javier JJ, Mustapha JA, Abizaid A, Lansky AJ. First-in-Human Study of Paclitaxel Drug-Coated Chocolate Coronary Percutaneous Transluminal Coronary Angioplasty Balloon Catheter in De Novo Coronary Artery Lesions. JACC Cardiovascular Interventions 2019, 12: 2568-2570. PMID: 31857033, DOI: 10.1016/j.jcin.2019.08.044.Peer-Reviewed Original Research
2013
TCT-600 Six-Month Results of the DESolve Novolimus-Eluting Bioresorbable Scaffold for the Treatment of Single, De Novo, Coronary Artery Lesions: Serial OCT Analysis from the Pivotal, Prospective Multicenter DESolve NX
Chamie D, Verheye S, Schofer J, Costa J, Costa R, Abizaid A, John Y, Bbhat V, Morrison L, Toyloy S, Abizaid A. TCT-600 Six-Month Results of the DESolve Novolimus-Eluting Bioresorbable Scaffold for the Treatment of Single, De Novo, Coronary Artery Lesions: Serial OCT Analysis from the Pivotal, Prospective Multicenter DESolve NX. Journal Of The American College Of Cardiology 2013, 62: b182. DOI: 10.1016/j.jacc.2013.08.1347.Peer-Reviewed Original ResearchTCT-20 Two-Year Clinical Follow-Up of the FIREHAWK Abluminal Groove-Filled Biodegradable Polymer Sirolimus-Eluting Stent in the Treatment of Patients with De Novo Native Coronary Artery Lesions: The TARGET I Trial
Xu B, Gao R, Lansky A, Yang Y, Changsheng M, Han Y, Chen S, Li H, Zhang R, Fu G, Yuan Z, Huo Y, Li W, Zhao Y, Leon M. TCT-20 Two-Year Clinical Follow-Up of the FIREHAWK Abluminal Groove-Filled Biodegradable Polymer Sirolimus-Eluting Stent in the Treatment of Patients with De Novo Native Coronary Artery Lesions: The TARGET I Trial. Journal Of The American College Of Cardiology 2013, 62: b7-b8. DOI: 10.1016/j.jacc.2013.08.748.Peer-Reviewed Original ResearchDe novo native coronary artery lesionsBiodegradable Polymer Sirolimus-Eluting StentNovo native coronary artery lesionsNative coronary artery lesionsCoronary artery lesionsSirolimus-eluting stentsTreatment of patientsTwo-Year ClinicalAbluminal grooveArtery lesionsI trialPatientsClinicalLesionsStentsTrialsProspective, multi-center evaluation of the desolve NX novolimus-eluting bioresorbable coronary scaffold: principal clinical and imaging endpoints
Abizaid A, Schofer J, Meng M, Witzenbichler B, Bothelho R, Costa J, Chamie D, Medical I, Ormiston J, Verheye S. Prospective, multi-center evaluation of the desolve NX novolimus-eluting bioresorbable coronary scaffold: principal clinical and imaging endpoints. European Heart Journal 2013, 34: p5547. DOI: 10.1093/eurheartj/eht310.p5547.Peer-Reviewed Original ResearchMajor adverse cardiac eventsCoronary scaffoldsBioresorbable coronary scaffoldsCoronary artery lesionsPercutaneous coronary interventionProcedural successClinical endpointsPolylactide-based polymersVascular scaffoldsArtery lesionsBioresorbable vascular scaffoldComposite endpoint of cardiac deathAnnually to 5 yearsEndpoint of cardiac deathMultiple clinical endpointsDe novo coronary artery lesionsDrug-eluting bioresorbable vascular scaffoldsAdverse cardiac eventsLong-term scaffoldTarget lesion revascularizationNative coronary artery lesionsTarget vessel revascularizationMultiple imaging modalitiesTarget vessel MIOCT assessmentEvaluation of XIENCE V Everolimus-Eluting and Taxus Express2 Paclitaxel-Eluting Coronary Stents in Patients With Jailed Side Branches From the SPIRIT IV Trial at 2 Years
Forrest JK, Lansky AJ, Meller SM, Hou L, Sood P, Applegate RJ, Wang JC, Skelding KA, Shah A, Kereiakes DJ, Sudhir K, Cristea E, Yaqub M, Stone GW. Evaluation of XIENCE V Everolimus-Eluting and Taxus Express2 Paclitaxel-Eluting Coronary Stents in Patients With Jailed Side Branches From the SPIRIT IV Trial at 2 Years. The American Journal Of Cardiology 2013, 111: 1580-1586. PMID: 23499270, DOI: 10.1016/j.amjcard.2013.01.330.Peer-Reviewed Original ResearchConceptsSPIRIT IV trialMajor adverse cardiac eventsAdverse cardiac eventsClinical outcomesXIENCE VTarget lesionsCardiac eventsNovo native coronary artery lesionsIschemia-driven target vessel revascularizationTwo-year clinical outcomesNative coronary artery lesionsSPIRIT IIISide branchesXIENCE V EverolimusTarget lesion failureTarget vessel revascularizationCoronary artery lesionsPercutaneous coronary interventionSuperior clinical outcomesTreatment of patientsCoronary stent systemDrug-eluting stentsDiverse patient populationsEverolimus-ElutingSPIRIT IV
2011
Diagnosis of Ischemia-Causing Coronary Stenoses by Noninvasive Fractional Flow Reserve Computed From Coronary Computed Tomographic Angiograms Results From the Prospective Multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) Study
Koo BK, Erglis A, Doh JH, Daniels DV, Jegere S, Kim HS, Dunning A, DeFrance T, Lansky A, Leipsic J, Min JK. Diagnosis of Ischemia-Causing Coronary Stenoses by Noninvasive Fractional Flow Reserve Computed From Coronary Computed Tomographic Angiograms Results From the Prospective Multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) Study. Journal Of The American College Of Cardiology 2011, 58: 1989-1997. PMID: 22032711, DOI: 10.1016/j.jacc.2011.06.066.Peer-Reviewed Original ResearchConceptsFractional flow reserveCoronary artery diseaseComputation of FFRInvasive coronary angiographyNoninvasive fractional flow reserveCCTA stenosisCoronary angiographyDiagnostic performanceFlow reserveCCTA dataPredictive valueObstructive coronary artery diseaseMeasurement of FFRComputed Tomographic AngiogramsIschemia-causing stenosisPercent of patientsCoronary artery lesionsIndependent core laboratoryInvasive fractional flow reserveThree-Year Results of Safety and Efficacy of the Everolimus-Eluting Coronary Stent in Women (from the SPIRIT III Randomized Clinical Trial)
Ng VG, Lansky AJ, Hermiller JB, Farhat N, Applegate RJ, Yaqub M, Sood P, Su X, Simonton CA, Sudhir K, Stone GW. Three-Year Results of Safety and Efficacy of the Everolimus-Eluting Coronary Stent in Women (from the SPIRIT III Randomized Clinical Trial). The American Journal Of Cardiology 2011, 107: 841-848. PMID: 21255760, DOI: 10.1016/j.amjcard.2010.10.068.Peer-Reviewed Original ResearchConceptsTarget vessel failure rateSPIRIT III trialXIENCE VIII trialsClinical outcomesLow major adverse cardiac event rateMajor adverse cardiac event ratesAdverse cardiac event ratesMajor adverse cardiac eventsTAXUS paclitaxel-eluting stentAdverse cardiac eventsCardiac event rateCoronary artery lesionsLong-term complicationsPaclitaxel-eluting stentsThree-year resultsLesion revascularizationArtery lesionsCardiac eventsComplication rateStent thrombosisTreatment armsClinical benefitTaxus stentSubset analysis
2010
Is Accurate Intravascular Ultrasound Evaluation of the Left Circumflex Ostium from a Left Anterior Descending to Left Main Pullback Possible?
Oviedo C, Maehara A, Mintz GS, Tsujita K, Kubo T, Doi H, Castellanos C, Lansky AJ, Mehran R, Dangas G, Leon MB, Stone GW, Templin B, Araki H, Ochiai M, Moses JW. Is Accurate Intravascular Ultrasound Evaluation of the Left Circumflex Ostium from a Left Anterior Descending to Left Main Pullback Possible? The American Journal Of Cardiology 2010, 105: 948-954. PMID: 20346311, DOI: 10.1016/j.amjcard.2009.11.029.Peer-Reviewed Original ResearchConceptsSide branch ostiumLeft circumflexIntravascular ultrasound evaluationLumen diameterBranch ostiumUltrasound evaluationLeft Main Coronary Artery Bifurcation LesionsMain coronary artery bifurcation lesionsMain coronary artery lesionsCoronary artery bifurcation lesionsCoronary artery bifurcation diseaseCoronary artery lesionsIntravascular ultrasound assessmentMain vesselOblique viewCircumflex ostiumArtery lesionsLeft anteriorBland-Altman plotsPlaque burdenLimits of agreementOstial LADUltrasound assessmentBifurcation diseaseBifurcation lesions
2009
Clinical and angiographic outcomes with an everolimus‐eluting stent in large coronary arteries: The SPIRIT III 4.0 mm registry
Gordon PC, Applegate RJ, Hermiller JB, Weinsier SB, Doostzadeh J, Cao S, Sudhir K, Lansky AJ, Stone GW. Clinical and angiographic outcomes with an everolimus‐eluting stent in large coronary arteries: The SPIRIT III 4.0 mm registry. Catheterization And Cardiovascular Interventions 2009, 75: 179-186. PMID: 19877267, DOI: 10.1002/ccd.22259.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCardiovascular AgentsCoronary AngiographyCoronary StenosisDrug-Eluting StentsEverolimusFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionPaclitaxelPredictive Value of TestsProspective StudiesRegistriesRisk AssessmentSingle-Blind MethodSirolimusThrombosisTime FactorsTreatment OutcomeUnited StatesConceptsMajor adverse cardiac eventsTarget vessel failureSegment late lossSPIRIT III trialLarge coronary arteriesPaclitaxel-eluting stentsLate lossCoronary arteryIII trialsXIENCE VDe novo native coronary artery lesionsNovo native coronary artery lesionsNative coronary artery lesionsPE armSPIRIT IIIAdverse cardiac eventsCoronary artery lesionsAdverse clinical eventsAngiographic late lossEES patientsNoninferior ratesPrimary endpointAngiographic outcomesArtery lesionsCardiac eventsSPIRIT IV trial design: A large-scale randomized comparison of everolimus-eluting stents and paclitaxel-eluting stents in patients with coronary artery disease
Nikolsky E, Lansky AJ, Sudhir K, Doostzadeh J, Cutlip DE, Piana R, Su X, White R, Simonton CA, Stone GW. SPIRIT IV trial design: A large-scale randomized comparison of everolimus-eluting stents and paclitaxel-eluting stents in patients with coronary artery disease. American Heart Journal 2009, 158: 520-526.e2. PMID: 19781409, DOI: 10.1016/j.ahj.2009.07.025.Peer-Reviewed Original ResearchConceptsPaclitaxel-eluting stentsTarget lesion revascularizationCoronary artery diseaseSPIRIT IVLesion revascularizationArtery diseaseDiabetes mellitusIschemia-driven target lesion revascularizationNovo native coronary artery lesionsMajor adverse cardiac eventsNative coronary artery diseaseNative coronary artery lesionsTarget vessel myocardial infarctionEnd pointUS clinical sitesAdverse cardiac eventsPrimary end pointTarget lesion failureTarget vessel failureVessel myocardial infarctionCoronary artery lesionsReference vessel diameterClinical end pointsMulticenter clinical trialAngiographic late lossGender‐based evaluation of the XIENCE V™ everolimus‐eluting coronary stent system:
Lansky AJ, Ng VG, Mutlu H, Cristea E, Guiran JB, Midei M, Newman W, Sanz M, Sood P, Doostzadeh J, Su X, White R, Cao S, Sudhir K, Stone GW. Gender‐based evaluation of the XIENCE V™ everolimus‐eluting coronary stent system:. Catheterization And Cardiovascular Interventions 2009, 74: 719-727. PMID: 19530147, DOI: 10.1002/ccd.22067.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCardiovascular AgentsCardiovascular DiseasesCoronary AngiographyCoronary Artery DiseaseCoronary RestenosisDrug-Eluting StentsEverolimusFemaleHumansKaplan-Meier EstimateLinear ModelsLogistic ModelsMaleMiddle AgedMyocardial InfarctionPaclitaxelProspective StudiesProsthesis DesignRisk AssessmentRisk FactorsSex FactorsSingle-Blind MethodSirolimusThrombosisTime FactorsTreatment OutcomeWomen's HealthConceptsSPIRIT III trialIII trialsXIENCE VTaxus stentXience V stentTVF rateTAXUS paclitaxel-eluting stentRate of MACECoronary artery lesionsStent thrombosis ratesPercutaneous coronary interventionStent late lossPaclitaxel-eluting stentsCoronary stent systemHigher MACEMore hypertensionAngiographic characteristicsArtery lesionsCoronary interventionThrombosis rateAngiographic resultsClinical outcomesClinical benefitStent placementSubset analysisImpact of Myocardial Bridge on Clinical Outcome After Coronary Stent Placement
Tsujita K, Maehara A, Mintz GS, Doi H, Kubo T, Castellanos C, Liu J, Yang J, Oviedo C, Franklin-Bond T, Sugirtharaj DD, Dangas GD, Lansky AJ, Stone GW, Moses JW, Leon MB, Mehran R. Impact of Myocardial Bridge on Clinical Outcome After Coronary Stent Placement. The American Journal Of Cardiology 2009, 103: 1344-1348. PMID: 19427426, DOI: 10.1016/j.amjcard.2009.01.340.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationCoronary stent placementStent placementMyocardial bridgeArtery lesionsObstructive lesionsClinical outcomesStent groupTarget lesion revascularization rateStent group patientsTarget vessel revascularizationComposite end pointCoronary artery lesionsMinimum stent areaGroup patientsRevascularization ratesConsecutive patientsLeft anteriorObstructive diseaseSystolic compressionCoronary arterySignificant plaqueStent areaStent restenosisIntravascular ultrasound
2007
Randomized, double‐blind, multicenter study of the polymer‐based 17‐β estradiol‐eluting stent for treatment of native coronary artery lesions: Six‐month results of the ETHOS I trial
Abizaid A, Chaves Á, Leon MB, Hauptmann K, Mehran R, Lansky AJ, Baumbach W, Shankar H, Muller R, Feres F, Sousa AG, Sousa JE, Grube E. Randomized, double‐blind, multicenter study of the polymer‐based 17‐β estradiol‐eluting stent for treatment of native coronary artery lesions: Six‐month results of the ETHOS I trial. Catheterization And Cardiovascular Interventions 2007, 70: 654-660. PMID: 17932898, DOI: 10.1002/ccd.21210.Peer-Reviewed Original ResearchConceptsStent volume obstructionIntravascular ultrasoundVolume obstructionI trialCoronary lesionsSingle de novo native coronary lesionsDe novo native coronary lesionsMean reference vessel diameterMajor adverse cardiac eventsNative coronary artery lesionsBinary angiographic restenosisAdverse cardiac eventsNative coronary lesionsPrimary end pointCoronary artery lesionsReference vessel diameterSix-month resultsStent late lossTreatment of patientsBare metal stentsMean lesion lengthLesion revascularizationAngiographic restenosisPrimary endpointSecondary endpoints
2006
Drug-Eluting Stents in the Treatment of Intermediate Lesions Pooled Analysis From Four Randomized Trials
Moses JW, Stone GW, Nikolsky E, Mintz GS, Dangas G, Grube E, Ellis SG, Lansky AJ, Weisz G, Fahy M, Na Y, Russell ME, Donohoe D, Leon MB, Mehran R. Drug-Eluting Stents in the Treatment of Intermediate Lesions Pooled Analysis From Four Randomized Trials. Journal Of The American College Of Cardiology 2006, 47: 2164-2171. PMID: 16750680, DOI: 10.1016/j.jacc.2006.01.068.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsDrug-eluting stentsTarget vessel revascularizationIntermediate lesionsAngiographic restenosisMyocardial infarctionCardiac deathStent thrombosisDe novo coronary artery lesionsIntroduction of DESLate major adverse cardiac eventsEfficacy of DESNovo coronary artery lesionsBinary angiographic restenosisAdverse cardiac eventsCoronary artery lesionsCurrent treatment paradigmsTreatment of patientsIntermediate coronary lesionsBalloon-expandable stentsLower ratesEverolimus trialsRestenosis reductionTAXUS IVVessel revascularizationFinal results from the multi-center trial of the angiosculpt scoring balloon catheter for the treatment of complex coronary artery lesions
Costa R, Mooney M, Teirstein P, Moses J, Turco M, Reisman M, Waksman R, Saucedo J, Mauri L, Lee D, Gershony G, Mehran R, Mintz G, Carlier S, Costa J, Cristea E, Dangas G, Lansky A, Leon M. Final results from the multi-center trial of the angiosculpt scoring balloon catheter for the treatment of complex coronary artery lesions. Cardiovascular Revascularization Medicine 2006, 7: 112. DOI: 10.1016/j.carrev.2006.03.068.Peer-Reviewed Original Research
2003
Benefits of cutting balloon before stenting.
Rizik DG, Popma JP, Leon MB, Mintz GS, Weiner B, Cohen E, Lansky AJ, Adem AM, Bouhasin AP, Wojciechowski C, Weissman NJ. Benefits of cutting balloon before stenting. Journal Of Invasive Cardiology 2003, 15: 624-8. PMID: 14608131.Peer-Reviewed Original ResearchConceptsMinimal stent cross-sectional areaStent cross-sectional areaStent implantationIntravascular ultrasoundCross-sectional areaCulprit coronary artery lesionStent percent diameter stenosisDe novo coronary lesionsSignificant coronary artery diseaseHospital complication ratesNovo coronary lesionsCoronary artery lesionsCoronary artery diseaseCoronary stent implantationAcute luminal gainPercent diameter stenosisQuantitative coronary angiographyArtery lesionsCulprit lesionStent restenosesArtery diseaseComplication rateCoronary angiographyCoronary lesionsBalloon angioplastySafety of an Aspirin-Alone Regimen After Intracoronary Stenting With a Heparin-Coated Stent
Mehran R, Aymong ED, Ashby DT, Fischell T, Whitworth H, Siegel R, Thomas W, Wong SC, Narasimaiah R, Lansky AJ, Leon MB. Safety of an Aspirin-Alone Regimen After Intracoronary Stenting With a Heparin-Coated Stent. Circulation 2003, 108: 1078-1083. PMID: 12925457, DOI: 10.1161/01.cir.0000086347.31341.f9.Peer-Reviewed Original ResearchConceptsStent thrombosisIntracoronary stentingNon-Q-wave myocardial infarctionMajor adverse cardiac eventsNative coronary artery lesionsAdverse cardiac eventsBlunt chest traumaPrimary end pointCoronary artery lesionsNative coronary arteriesDevastating clinical consequencesBalloon-expandable stentsAspirin monotherapyAnticoagulation therapyArtery lesionsCardiac eventsChest traumaInfrequent complicationSelect patientsProcedural successRestenotic lesionsCoronary arteryOptimal stentingMyocardial infarctionClinical consequences
2001
Acute and 6‐month clinical and angiographic outcome after implantation of the ACS Duet stent for single‐vessel coronary artery disease: Final results of the European and U.S. ACS Multi‐link Duet Registry
Foley D, Kererakes D, Riele J, Nishimura N, Veldhof S, Fink S, Yeung A, van Hoogenhuyze D, Lansky A, van Es G, Kutryk M, Serruys P. Acute and 6‐month clinical and angiographic outcome after implantation of the ACS Duet stent for single‐vessel coronary artery disease: Final results of the European and U.S. ACS Multi‐link Duet Registry. Catheterization And Cardiovascular Interventions 2001, 54: 25-33. PMID: 11553944, DOI: 10.1002/ccd.1233.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseaseSingle-vessel coronary artery diseaseMajor adverse cardiac eventsNative coronary artery lesionsObstructive coronary artery diseaseEffective percutaneous treatmentAdverse cardiac eventsCoronary artery lesionsProspective observational studyMinimum luminal diameterQuantitative coronary angiographyCoronary stent systemAdequate predilatationAngiographic outcomesArtery lesionsCardiac eventsCoronary angiographyPercutaneous treatmentRestenosis rateTarget lesionsLate outcomesLuminal diameterObservational studyStent system
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