2024
Mapping the influence of hydrocarbons mixture on molecular mechanisms, involved in breast and lung neoplasms: in silico toxicogenomic data-mining
Abu-Bakar A, Ismail M, Zulkifli M, Zaini N, Shukor N, Harun S, Inayat-Hussain S. Mapping the influence of hydrocarbons mixture on molecular mechanisms, involved in breast and lung neoplasms: in silico toxicogenomic data-mining. Genes And Environment 2024, 46: 15. PMID: 38982523, PMCID: PMC11232146, DOI: 10.1186/s41021-024-00310-y.Peer-Reviewed Original ResearchNon-apoptotic programmed cell deathSignaling pathwayMolecular mechanismsResponse to oxidative stressInterleukin-17 signaling pathwayMolecular pathwaysSurvival signaling pathwaysAdaptive response to oxidative stressOxidative stress responseBreast cancer invasionGenetic interactionsModulate IL-8Protein domainsCytoscape softwareAir pollutionCritical genesCell deathCo-expressionGenesRisk of breastStress responseToxicogenomic analysisToxicogenomics toolsDevelopment of breastInvestigated hydrocarbons
2017
Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension
Chen P, Cao A, Miyagawa K, Tojais N, Hennigs J, Li C, Sweeney N, Inglis A, Wang L, Li D, Ye M, Feldman B, Rabinovitch M. Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension. JCI Insight 2017, 2: e90427. PMID: 28138562, PMCID: PMC5256132, DOI: 10.1172/jci.insight.90427.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmphetamine-Related DisordersAmphetaminesAnimalsCaspase 3DNA DamageElectron TransportEndothelial CellsFemaleHumansHypertension, PulmonaryHypoxiaHypoxia-Inducible Factor 1, alpha SubunitIn Vitro TechniquesMaleMethamphetamineMiceMiddle AgedMitochondriaOxidative PhosphorylationProtein Phosphatase 2Protein Serine-Threonine KinasesProto-Oncogene Proteins c-aktPulmonary ArteryPyruvate Dehydrogenase Acetyl-Transferring KinaseReactive Oxygen SpeciesSirtuin 1Vascular RemodelingConceptsPulmonary artery endothelial cellsPulmonary arterial hypertensionDNA damageHypoxic pulmonary artery endothelial cellsDoses of methamphetaminePulmonary vascular remodelingImpaired electron transportActivity of protein phosphatase 2AProtein phosphatase 2AResponse to oxidative stressOxidative stressMitochondrial oxidative phosphorylationArtery endothelial cellsInhibition of AktAdaptive response to oxidative stressMitochondrial ROS increaseBinge dosesDNA damage fociPulmonary hypertensionPyruvate dehydrogenase kinase 1Arterial hypertensionIncreased sirtuin 1Phosphatase 2ATranscriptional activityVascular remodeling
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