2023
Somatic loss of ATM is a late event in pancreatic tumorigenesis
Paranal R, Jiang Z, Hutchings D, Kryklyva V, Gauthier C, Fujikura K, Nanda N, Huang B, Skaro M, Wolfgang C, He J, Klimstra D, Brand R, Singhi A, DeMarzo A, Zheng L, Goggins M, Brosens L, Hruban R, Klein A, Lotan T, Wood L, Roberts N. Somatic loss of ATM is a late event in pancreatic tumorigenesis. The Journal Of Pathology 2023, 260: 455-464. PMID: 37345735, PMCID: PMC10524278, DOI: 10.1002/path.6136.Peer-Reviewed Original ResearchConceptsGermline ATM variantsPancreatic precursor lesionsATM variantsPrecursor lesionsPancreatic ductal adenocarcinomaInvasive pancreatic adenocarcinomaATM statusATM alterationsPancreatic adenocarcinomaColloid carcinomaDuctal adenocarcinomaPancreatic tumorigenesisATM expressionInvasive pancreatic ductal adenocarcinomaSpectrum of genetic alterationsDevelopment of pancreatic cancerLoss of protein expressionLesions of patientsLoss of ATM expressionLoss of ATMPancreatic cancerSomatic lossGenetic alterationsAdenocarcinomaPatients
2016
Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice
Seifert L, Werba G, Tiwari S, Ly N, Nguy S, Alothman S, Alqunaibit D, Avanzi A, Daley D, Barilla R, Tippens D, Torres-Hernandez A, Hundeyin M, Mani VR, Hajdu C, Pellicciotta I, Oh P, Du K, Miller G. Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice. Gastroenterology 2016, 150: 1659-1672.e5. PMID: 26946344, PMCID: PMC4909514, DOI: 10.1053/j.gastro.2016.02.070.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaImmune suppressive phenotypeT cell responsesRadiation therapyT cellsTumor growthControl micePancreatic tumorsT cell-mediated anti-tumor responsesAdvanced unresectable pancreatic ductal adenocarcinomaAnti-tumor T cell responsesInvasive pancreatic ductal adenocarcinomaSuppress T cell responsesUnresectable pancreatic ductal adenocarcinomaMurine pancreatic ductal adenocarcinomaPancreatic intraepithelial lesionsAnti-tumor responseT helper 2Treatment of patientsRegulatory cell phenotypeM2-like phenotypePhenotype of macrophagesAdoptive transferKC miceUnexposed mice
2015
Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia is a risk factor for the subsequent development of pancreatic ductal adenocarcinoma
Rezaee N, Barbon C, Zaki A, He J, Salman B, Hruban RH, Cameron JL, Herman JM, Ahuja N, Lennon AM, Weiss MJ, Wood LD, Wolfgang CL. Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia is a risk factor for the subsequent development of pancreatic ductal adenocarcinoma. Hepato Pancreato Biliary 2015, 18: 236-246. PMID: 27017163, PMCID: PMC4814593, DOI: 10.1016/j.hpb.2015.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Pancreatic DuctalDatabases, FactualDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedNeoplasm GradingNeoplasm InvasivenessNeoplasms, Cystic, Mucinous, and SerousNeoplasms, Second PrimaryPancreatectomyPancreatic NeoplasmsProportional Hazards ModelsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsIntraductal papillary mucinous neoplasmHigh-grade dysplasiaPancreatic ductal adenocarcinomaNon-invasive intraductal papillary mucinous neoplasmsIntermediate-grade dysplasiaPapillary mucinous neoplasmRemnant pancreasVascular invasionMucinous neoplasmsDuctal adenocarcinomaInvasive pancreatic ductal adenocarcinomaMedian overall survivalLymph node metastasisRate of progressionSubsequent developmentIntermediate dysplasiaPancreatic resectionOverall survivalNode metastasisPerineural invasionMalignant entitiesRisk factorsPatientsDysplasiaPancreas
2004
An Illustrated Consensus on the Classification of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms
Hruban R, Takaori K, Klimstra D, Adsay N, Albores-Saavedra J, Biankin A, Biankin S, Compton C, Fukushima N, Furukawa T, Goggins M, Kato Y, Klppel G, Longnecker D, Lttges J, Maitra A, Offerhaus G, Shimizu M, Yonezawa S. An Illustrated Consensus on the Classification of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms. The American Journal Of Surgical Pathology 2004, 28: 977-987. PMID: 15252303, DOI: 10.1097/01.pas.0000126675.59108.80.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmPapillary mucinous neoplasmPancreatic intraepithelial neoplasiaMucinous cystic neoplasmsPrecursor lesionsIntraepithelial neoplasiaMucinous neoplasmsDiagnostic criteriaCystic neoplasmsPancreatic cancerDuctal adenocarcinomaPancreatic ductInvasive pancreatic ductal adenocarcinomaOvarian-type stromaPrecursor lesions of pancreatic cancerEarly pancreatic cancerInvasive ductal adenocarcinomaThe Johns Hopkins HospitalNoninvasive precursor lesionsPancreatic ductal adenocarcinomaJohns Hopkins HospitalMucin-containing cellsNoninvasive neoplasmsNoninvasive precursorsInvasive adenocarcinoma
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