2024
A Seamless Phase 2A‐Phase 2B Multi‐Center Trial to Test the Benefits of Benfotiamine on the Progression of Alzheimer’s Disease‐Benfoteam: Design and Methods
Luchsinger J, Feldman H, Messer K, Edland S, Leger G, Jacobs D, Salmon D, Revta C, Lupo J, Durant J, Gibson G. A Seamless Phase 2A‐Phase 2B Multi‐Center Trial to Test the Benefits of Benfotiamine on the Progression of Alzheimer’s Disease‐Benfoteam: Design and Methods. Alzheimer's & Dementia 2024, 20: e091963. PMCID: PMC11714007, DOI: 10.1002/alz.091963.Peer-Reviewed Original ResearchPhase 2bDosing decisionsPerson-months of exposureLonger-term safetyWeeks of treatmentCo-primary endpointsClinically significant benefitBiomarker test resultsMulti-center trialTolerated doseDouble-blindEvaluate safetySmall molecule treatmentBlood levelsActive treatmentPhase 2aThiamine deficiencyPerson-monthsDoseCohen's d effect sizesPharmacological effectsTherapeutic directionsBenfotiamineGlucose metabolismMg/day
2023
Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia
Gou M, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Li C, Zhang P, Huang J, Tian L, Hong L, Tan Y. Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia. Molecular Neurobiology 2023, 61: 2754-2763. PMID: 37932545, DOI: 10.1007/s12035-023-03694-0.Peer-Reviewed Original ResearchImmune-inflammatory response systemWhite matter integrityEnzyme-linked immunosorbent assayDiffusion tensor imagingD effect sizesFractional anisotropyWhole-brain white matter integritySex-matched healthy controlsReflex systemPlasma cytokine levelsFirst-episode patientsBrains of patientsBrain white matter integrityCortico-spinal tractNegative Syndrome ScaleCohen's d effect sizesAverage fractional anisotropyImmune imbalancePeripheral cytokinesCytokine levelsInflammatory mediatorsEpisode patientsPathophysiological mechanismsWhite matter microstructureFunctional dysconnectivity
2022
Selfie Videos to Reduce Stigma and Increase Treatment Seeking Among Youths: Two Noninferiority Randomized Controlled Trials
Amsalem D, Jankowski SE, Pagdon S, Valeri L, Yang LH, Markowitz JC, Neria Y, Pescosolido BA, Dixon LB, Martin A. Selfie Videos to Reduce Stigma and Increase Treatment Seeking Among Youths: Two Noninferiority Randomized Controlled Trials. Psychiatric Services 2022, 74: 229-236. PMID: 36254455, DOI: 10.1176/appi.ps.20220168.Peer-Reviewed Original ResearchConceptsTreatment-seeking intentionsControl conditionBrief videoD effect sizesIntervention videoYoung adultsIllness-related stigmaMental health stigmaAdolescent depressionCohen's d effect sizesHealth stigmaStudy 2Study 1Treatment engagementThemes of recoveryAdolescentsEffect sizeShort videosRepeated-measures analysisStigmaIntentionSimilar efficacyAdultsVideoSocial media influencers
2019
Interictal Hyperperfusion in the Higher Visual Cortex in Patients With Episodic Migraine
Michels L, Villanueva J, O’Gorman R, Muthuraman M, Koirala N, Büchler R, Gantenbein A, Sandor P, Luechinger R, Kollias S, Riederer F. Interictal Hyperperfusion in the Higher Visual Cortex in Patients With Episodic Migraine. Headache The Journal Of Head And Face Pain 2019, 59: 1808-1820. PMID: 31680242, DOI: 10.1111/head.13646.Peer-Reviewed Original ResearchConceptsCerebral blood flowCohen's d effect sizesEpisodic migraineD effect sizesHealthy controlsSuperior temporal gyrusASL-MRIVisual cortexInterictal cerebral blood flowInterictal stateTemporal gyrusHigher-order visual cortexNeuro-functional abnormalitiesEffect sizeFunctional brain imaging studiesNon-invasive imaging methodMagnetic resonance imagingHigher visual cortexBrain imaging studiesInterictal hyperperfusionCBF changesSubcortical alterationsMigraine pathophysiologyParietal operculumBlood flow
2016
Effects of exercise interventions during different treatments in breast cancer.
Fairman C, Focht B, Lucas A, Lustberg M. Effects of exercise interventions during different treatments in breast cancer. The Journal Of Community And Supportive Oncology 2016, 14: 200-9. PMID: 27258052, PMCID: PMC5522734, DOI: 10.12788/jcso.0225.Peer-Reviewed Original ResearchExercise interventionD effect sizesTreatment-related adverse effectsFemale breast cancer survivorsPsychosocial outcomesEfficacy of exerciseBreast cancer survivorsBreast cancer patientsBreast cancer treatmentActive cancer therapyPost-treatment interventionsType of treatmentCohen's d effect sizesCancer survivorsResistance exerciseAerobic exerciseCancer patientsInclusion criteriaMuscular strengthCardiovascular functioningLiterature searchCancer treatmentAdverse effectsModerate improvementCancer therapy
2014
A single session of exercise increases connectivity in sensorimotor-related brain networks: a resting-state fMRI study in young healthy adults
Rajab AS, Crane DE, Middleton LE, Robertson AD, Hampson M, MacIntosh BJ. A single session of exercise increases connectivity in sensorimotor-related brain networks: a resting-state fMRI study in young healthy adults. Frontiers In Human Neuroscience 2014, 8: 625. PMID: 25177284, PMCID: PMC4132485, DOI: 10.3389/fnhum.2014.00625.Peer-Reviewed Original ResearchResting-state networksYoung healthy adultsFunctional connectivityD effect sizesHealthy adultsSingle sessionModerate-intensity aerobic exerciseLong-term physical activityResting-state functional magnetic resonance imagingResting-state fMRI studyExercise control groupSession effectsIntensity aerobic exerciseSecondary somatosensory areaTerm physical activityFunctional magnetic resonance imagingMagnetic resonance imagingBrain functional connectivityCohen's d effect sizesExercise findingsAcute exerciseTest-retest reliabilityAerobic exerciseBrain effectsAcute effects
2007
Meta-Analysis of Psychological Interventions for Chronic Low Back Pain
Hoffman BM, Papas RK, Chatkoff DK, Kerns RD. Meta-Analysis of Psychological Interventions for Chronic Low Back Pain. Health Psychology 2007, 26: 1-9. PMID: 17209691, DOI: 10.1037/0278-6133.26.1.1.Peer-Reviewed Original ResearchConceptsChronic low back painLow back painPain intensityBack painD effect sizesPsychological interventionsInclusion criteriaHealth care provider visitsComputer-aided literature searchHealth-related qualityPain-related interferenceHealth care utilizationRandom-effects modelCohen's d effect sizesMinimal publication biasEffect sizeSelf-regulatory treatmentPain medicationProvider visitsActive control conditionCare utilizationPain interferenceCompensation statusClinical trialsPositive short-term effects
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