2018
The L-type calcium channel blocker, isradipine, attenuates cue-induced cocaine-seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway
Addy NA, Nunes EJ, Hughley SM, Small KM, Baracz SJ, Haight JL, Rajadhyaksha AM. The L-type calcium channel blocker, isradipine, attenuates cue-induced cocaine-seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway. Neuropsychopharmacology 2018, 43: 2361-2372. PMID: 29773910, PMCID: PMC6180103, DOI: 10.1038/s41386-018-0080-2.Peer-Reviewed Original ResearchConceptsL-type calcium channelsCocaine relapseLever depressionVentral tegmental areaCocaine self-administration trainingOriginal training contextLight cue presentationSelf-administration trainingSubjective effectsCocaine-seeking behaviorTegmental areaBehavioral effectsCocaine's subjective effectsL-type calcium channel blockerCue presentationMale Sprague-Dawley ratsTraining contextCocaine cuesNucleus accumbens coreNatural rewardsDA receptor activationCalcium channel blockersSprague-Dawley ratsPhasic dopaminePotential therapeutic target
2012
Nicotine-taking and nicotine-seeking in C57Bl/6J mice without prior operant training or food restriction
Yan Y, Pushparaj A, Gamaleddin I, Steiner RC, Picciotto MR, Roder J, Le Foll B. Nicotine-taking and nicotine-seeking in C57Bl/6J mice without prior operant training or food restriction. Behavioural Brain Research 2012, 230: 34-39. PMID: 22326373, PMCID: PMC3310267, DOI: 10.1016/j.bbr.2012.01.042.Peer-Reviewed Original ResearchConceptsNose-poke behaviorPrior operant trainingFood restrictionDose-response curveNicotine-seeking behaviorC57BL/6J miceIntermittent footshockFlat dose-response curveNaive C57BL/6J miceInjections of nicotineOperant trainingNicotine self-administration paradigmSelf-administration paradigmCue presentationSelf-administered salineNicotine groupNicotine reinforcementLight cue presentationPriming injectionsFR2 scheduleSecond consecutive dayConsecutive daysMiceDaily sessionsNicotine
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