Glucocorticoid regulation of the circadian clock modulates glucose homeostasis
So A, Bernal T, Pillsbury M, Yamamoto K, Feldman B. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 17582-17587. PMID: 19805059, PMCID: PMC2757402, DOI: 10.1073/pnas.0909733106.Peer-Reviewed Original ResearchConceptsGlucocorticoid response elementClock genesGlucocorticoid regulationGenes in vivoCore clock gene Per2Circadian clock genesGenomic deletionsMultiple clock genesClock gene Per2Response elementRegulatory pathwaysRhythmic expressionGenesPeripheral clocksGlucose homeostasisElevated leptin levelsAction of glucocorticoidsPhysiological consequencesRegulationGlucocorticoid receptorPer2Glucocorticoid treatmentLeptin levelsMuscle wastingGlucose intolerance
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