2018
Modeling Strengthens Molecular Link between Circadian Polymorphisms and Major Mood Disorders
Liberman AR, Halitjaha L, Ay A, Ingram KK. Modeling Strengthens Molecular Link between Circadian Polymorphisms and Major Mood Disorders. Journal Of Biological Rhythms 2018, 33: 318-336. PMID: 29614896, DOI: 10.1177/0748730418764540.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsCircadian phenotypesMammalian circadian clockCircadian gene expressionCLOCK polymorphismsClock gene mutationsRecent genetic studiesIntronic single nucleotide polymorphismKnockdown conditionsCircadian clockTranscription rateMolecular linkGene expressionCircadian genesMolecular mechanismsGenetic studiesFunction mutationsNucleotide polymorphismsLength polymorphismClock gene polymorphismsGenotypic associationPolymorphismGene variantsMutationsPhenotypeCLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues
Luciano AK, Zhou W, Santana JM, Kyriakides C, Velazquez H, Sessa WC. CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues. Journal Of Biological Chemistry 2018, 293: 9126-9136. PMID: 29588368, PMCID: PMC5995495, DOI: 10.1074/jbc.ra117.000773.Peer-Reviewed Original ResearchConceptsCircadian locomotor output cycles kaputCLOCK phosphorylationCircadian gene expressionPhosphorylation sitesGene expressionNovel phosphorylation sitesClock-controlled genesCRISPR/Cas9 technologyNovel Akt substrateE-box elementsCore circadian genesAkt substrateTranscription factorsE-boxCentral circadian rhythmNuclear localizationNegative regulatorCas9 technologyNuclear accumulationCircadian genesInsulin-sensitive tissuesNuclear translocationPhosphorylationExpression levelsSer-845
2017
Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression
Luciano AK, Santana JM, Velazquez H, Sessa WC. Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression. Journal Of Biological Rhythms 2017, 32: 212-221. PMID: 28452287, PMCID: PMC5703205, DOI: 10.1177/0748730417704534.Peer-Reviewed Original ResearchConceptsCircadian gene expressionCircadian regulatorsAmplitude of expressionGene expressionAkt isoformsIsoforms of AktCircadian transcriptionOrganismal levelPositive regulatorNormal behavioral rhythmsCircadian rhythmPeripheral clocksBehavioral rhythmsAKT1RegulatorAktIsoformsMammalsAmplitude rhythmsDaily rhythmsDifferent functionsLow-amplitude rhythmExpressionEndothelial cellsMice exhibit
2015
Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC)
Jim HS, Lin HY, Tyrer JP, Lawrenson K, Dennis J, Chornokur G, Chen Z, Chen AY, Permuth-Wey J, Aben KK, Anton-Culver H, Antonenkova N, Bruinsma F, Bandera EV, Bean YT, Beckmann MW, Bisogna M, Bjorge L, Bogdanova N, Brinton LA, Brooks-Wilson A, Bunker CH, Butzow R, Campbell IG, Carty K, Chang-Claude J, Cook LS, Cramer DW, Cunningham JM, Cybulski C, Dansonka-Mieszkowska A, du Bois A, Despierre E, Sieh W, Doherty JA, Dörk T, Dürst M, Easton DF, Eccles DM, Edwards RP, Ekici AB, Fasching PA, Fridley BL, Gao YT, Gentry-Maharaj A, Giles GG, Glasspool R, Goodman MT, Gronwald J, Harter P, Hasmad HN, Hein A, Heitz F, Hildebrandt MA, Hillemanns P, Hogdall CK, Hogdall E, Hosono S, Iversen ES, Jakubowska A, Jensen A, Ji BT, Karlan BY, Kellar M, Kiemeney LA, Krakstad C, Kjaer SK, Kupryjanczyk J, Vierkant RA, Lambrechts D, Lambrechts S, Le ND, Lee AW, Lele S, Leminen A, Lester J, Levine DA, Liang D, Lim BK, Lissowska J, Lu K, Lubinski J, Lundvall L, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, McNeish I, Menon U, Milne RL, Modugno F, Thomsen L, Moysich KB, Ness RB, Nevanlinna H, Eilber U, Odunsi K, Olson SH, Orlow I, Orsulic S, Weber R, Paul J, Pearce CL, Pejovic T, Pelttari LM, Pike MC, Poole EM, Schernhammer E, Risch HA, Rosen B, Rossing MA, Rothstein JH, Rudolph A, Runnebaum IB, Rzepecka IK, Salvesen HB, Schwaab I, Shu XO, Shvetsov YB, Siddiqui N, Song H, Southey MC, Spiewankiewicz B, Sucheston-Campbell L, Teo SH, Terry KL, Thompson PJ, Tangen IL, Tworoger SS, van Altena AM, Vergote I, Walsh CS, Wang-Gohrke S, Wentzensen N, Whittemore AS, Wicklund KG, Wilkens LR, Wu AH, Wu X, Woo YL, Yang H, Zheng W, Ziogas A, Amankwah E, Berchuck A, Schildkraut J, Kelemen JM, Ramus LE, Monteiro SJ, Goode AN, Narod EL, Gayther SA, Pharoah SA, Sellers PD, Phelan TA. Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC). Journal Of Genetics And Genome Research 2015, 2: 017. PMID: 26807442, PMCID: PMC4722961, DOI: 10.23937/2378-3648/1410017.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsCircadian genesGenetic variationDownstream transcription factorsCircadian gene expressionCommon genetic variationGenotyped single nucleotide polymorphismsCircadian rhythm genesOvarian surface epithelial cellsAlternative splicingTranscription factorsGene expressionFunctional analysisHormonal pathwaysOvarian Cancer Association ConsortiumRhythm genesGenesGenotype dataNucleotide polymorphismsSurface epithelial cellsEpithelial cellsEnvironmental factorsGranulosa cellsOvarian cancerEpithelial ovarian cancer
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