2021
Egg Freezing Activists:
Inhorn M. Egg Freezing Activists:. 2021, 47-59. DOI: 10.4324/9781003082422-4.Peer-Reviewed Original Research
2019
Cyclin E Overexpression in Human Mammary Epithelial Cells Promotes Epithelial Cancer-Specific Copy Number Alterations
Giraldez S, Tamayo P, Wineinger N, Kim W, Reed S. Cyclin E Overexpression in Human Mammary Epithelial Cells Promotes Epithelial Cancer-Specific Copy Number Alterations. IScience 2019, 19: 850-859. PMID: 31513970, PMCID: PMC6739637, DOI: 10.1016/j.isci.2019.08.043.Peer-Reviewed Original ResearchChromosomal copy number alterationsCopy number alterationsCyclin ECell cycle regulatory proteinsOverexpression of cyclin EChromosomal lociCyclin E overexpressionEpithelial cell clonesRegulatory proteinsReplication stressCell cycleAberrant mitosesS phaseEpithelial-like tumorsCyclinE overexpressionCell clonesClonesOncogenesisComputational approachReplicationPotential mechanismsChromosomal damageCellsLoci
2018
A role for telomere length and chromosomal damage in idiopathic pulmonary fibrosis
McDonough JE, Martens DS, Tanabe N, Ahangari F, Verleden SE, Maes K, Verleden GM, Kaminski N, Hogg JC, Nawrot TS, Wuyts WA, Vanaudenaerde BM. A role for telomere length and chromosomal damage in idiopathic pulmonary fibrosis. Respiratory Research 2018, 19: 132. PMID: 29986708, PMCID: PMC6038197, DOI: 10.1186/s12931-018-0838-4.Peer-Reviewed Original ResearchConceptsIPF lungsDisease severityChromosomal damagePulmonary fibrosisTelomere lengthBackgroundIdiopathic pulmonary fibrosisRegional disease severityStructural disease severityIdiopathic pulmonary fibrosisFatal lung diseaseAirway epithelial cellsMultivariate linear mixed-effects modelDonor lungsFibroblastic fociLung diseaseFibrotic markersTransplant surgeryPathological changesSevere diseaseLungLinear mixed-effects modelsQuantitative histologyMixed-effects modelsExtracellular matrixSeverity
2014
Chromosomal Aberrations and Exon 1 Mutation in the AKR1B1 Gene in Patients with Diabetic Neuropathy.
Saraswathy R, Anand S, Kunnumpurath SK, Kurian RJ, Kaye AD, Vadivelu N. Chromosomal Aberrations and Exon 1 Mutation in the AKR1B1 Gene in Patients with Diabetic Neuropathy. Ochsner Journal 2014, 14: 339-42. PMID: 25249799, PMCID: PMC4171791.Peer-Reviewed Original ResearchType 2 diabetes mellitusPainful diabetic neuropathyDiabetic neuropathyAKR1B1 geneDiabetes mellitusChromosomal aberrationsNeuropathic pathogenesisTremendous morbidityDM patientsTreatment optionsNeuropathyOxidative DNA damageExon 1 mutationsPatientsControl groupPathophysiological processesCultured lymphocytesPatient samplesChromosomal damagePilot investigationHigh rateSignificant mutationsPossible mutationsDNA damageSignificant number
2010
Influence of GSTs, CYP2E1 and mEH polymorphisms on 1, 3-butadiene-induced micronucleus frequency in Chinese workers
Tan H, Wang Q, Wang A, Ye Y, Feng N, Feng X, Lu L, Au W, Zheng Y, Xia Z. Influence of GSTs, CYP2E1 and mEH polymorphisms on 1, 3-butadiene-induced micronucleus frequency in Chinese workers. Toxicology And Applied Pharmacology 2010, 247: 198-203. PMID: 20637790, DOI: 10.1016/j.taap.2010.07.006.Peer-Reviewed Original ResearchConceptsGenotypes of GSTM1Higher MN frequencyMicronucleus frequencyChromosomal damageNon-exposed healthy individualsMN frequencyPolymorphisms of GSTM1Lower micronucleus frequencyBD exposure levelsPeripheral lymphocytesHealthy individualsMEH polymorphismsMetabolic polymorphismsBD exposureGSTM1CYP2E1Exposure levelsHigh groupCBMN assayLow exposureHuman carcinogenPCR-RFLPChromosome damageIntermediate groupPresent study
1995
Induction of p53 in mouse cells decreases mutagenesis by UV radiation
Yuan J, Yeasky T, Havre P, Glazer P. Induction of p53 in mouse cells decreases mutagenesis by UV radiation. Carcinogenesis 1995, 16: 2295-2300. PMID: 7586125, DOI: 10.1093/carcin/16.10.2295.Peer-Reviewed Original ResearchConceptsInduction of p53Cell cycle blockCell linesCycle blockRole of p53Cell cycle analysisInvolvement of p53Lambda phage shuttle vectorWestern blotChromosomal damageClonogenic survivalNucleotide excision repairUV-induced mutationsCellular DNA damageP53 alleleRecent evidenceP53Recoverable lambda phage shuttle vectorFibroblast cell lineMutation reporter geneUV-induced lesionsG1 phaseP53 activityMouse fibroblast cell lineReporter geneEffect of magnetic resonance exposure combined with gadopentetate dimeglumine on chromosomes in animal specimens
Rofsky N, Pizzarello D, Duhaney M, Falick A, Prendergast N, Weinreb J. Effect of magnetic resonance exposure combined with gadopentetate dimeglumine on chromosomes in animal specimens. Academic Radiology 1995, 2: 492-496. PMID: 9419596, DOI: 10.1016/s1076-6332(05)80405-2.Peer-Reviewed Original Research
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