2023
Studies in humans and mice reveal a critical role for CCR2 in trafficking of pDCs during infection with SARS-CoV-2
Zhang H, Lu X, Garner D, Parween F, Singh S, Majumdar S, Weaver J, Stein S, Lesho P, Damcott C, Lutfi F, Petrick K, Rock P, Chertow D, Kelsall B, Murphy P, Dahiya S, Hardy N, Farber J. Studies in humans and mice reveal a critical role for CCR2 in trafficking of pDCs during infection with SARS-CoV-2. The Journal Of Immunology 2023, 210: 143.04-143.04. DOI: 10.4049/jimmunol.210.supp.143.04.Peer-Reviewed Original ResearchMAIT cellsSARS-CoV-2Chemokine receptorsCCR2-deficient miceHospitalized COVID-19 patientsCOVID-19 pathogenesisBlood pDCCOVID-19 patientsReporter miceAffecting disease severityCCR2 ligandsCCR2III interferonsBlood leukocytesType 1ChemokinesDisease severityIncreased MortalityBlood cellsReceptorsAbsolute numberLeukocyte extravasationLungTransendothelial migrationBloodTh1 bias of liver mucosal‐associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus
Tang W, Ge K, Shen L, Wang H, Feng W, Sun X, Chu X, Zhu D, Yin H, Bi Y. Th1 bias of liver mucosal‐associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus. Diabetes/Metabolism Research And Reviews 2023, 39: e3620. PMID: 36738300, DOI: 10.1002/dmrr.3620.Peer-Reviewed Original ResearchConceptsHepatic MAIT cellsMAIT cellsMAIT cell subsetsType 2 diabetes mellitusInnate-like T cell subsetMucosal-associated invariant T (MAIT) cellsHepatic gluconeogenesisMucosal-Associated Invariant T CellsExpression of pyruvate carboxylaseGene expression of pyruvate carboxylaseCell subsetsExpression of genesT2DM subjectsInvariant T cellsIFN-gMAIT cell frequencyPyruvate carboxylaseProduction of interleukin-17HepG2 cells co-culturedT cell subsetsTumor necrosis factor-aDevelopment of type 2 diabetes mellitusGene expressionDiagnosed T2DM subjectsMetabolic homoeostasis
2017
C/EBPd enables the efficient extravasation of human CCR2+ MAIT cells
Zhang H, Lee C, Too L, Singh S, Tsang H, Kabat J, Singh T, Farber J. C/EBPd enables the efficient extravasation of human CCR2+ MAIT cells. The Journal Of Immunology 2017, 198: 143.10-143.10. DOI: 10.4049/jimmunol.198.supp.143.10.Peer-Reviewed Original ResearchMAIT cellsHuman umbilical vein endothelial cellsT cellsHuman mucosal-associated invariant T (MAIT) cellsMucosal-associated invariant T (MAIT) cellsBZIP transcription factorsResponse to pathogen challengeHuman MAIT cellsCD8+ T cellsExpression of FUT7Activated human umbilical vein endothelial cellsChemokine receptor CCR6Non-redundant roleSelectin ligandsSites of inflammationPathogen challengeTranscription factorsUmbilical vein endothelial cellsMR1-restrictedCD8+Receptor CCR6Efficient extravasationInflamed skinVein endothelial cellsChemokine receptors
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply