2024
Ligand‐gated ion channels as potential biomarkers for ADT‐mediated cognitive decline in prostate cancer patients
Verma S, Singh V, Nagampalli V, Ponsky L, Li C, Chao H, Gupta S. Ligand‐gated ion channels as potential biomarkers for ADT‐mediated cognitive decline in prostate cancer patients. Molecular Carcinogenesis 2024, 63: 1051-1063. PMID: 38482990, PMCID: PMC11096008, DOI: 10.1002/mc.23708.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyN-methyl-D-aspartate receptorsGamma-aminobutyric acidLigand-gated ion channelsType 1 angiotensin II receptorGlial cellsAndrogen signaling inhibitorsProstate cancer cell culture modelHigher risk of cognitive dysfunctionProstate cancer patientsPotential biomarkersBrain-derived neurotrophic factorCognitive dysfunctionIon channelsProtein-protein interaction network analysisAngiotensin II receptorsNuclear receptor subfamily 3 group C member 1Real-time polymerase chain reaction assayBrain glial cellsCytokine-cytokine receptor interactionCancer cell culture modelsAnalysis of genesGene-disease associationsInteraction network analysisPolymerase chain reaction assay
2012
Global Gene Expression Profiling of Proliferative Phase Endometrium Reveals Distinct Functional Subdivisions
Petracco RG, Kong A, Grechukhina O, Krikun G, Taylor HS. Global Gene Expression Profiling of Proliferative Phase Endometrium Reveals Distinct Functional Subdivisions. Reproductive Sciences 2012, 19: 1138-1145. PMID: 22623515, PMCID: PMC4052207, DOI: 10.1177/1933719112443877.Peer-Reviewed Original ResearchMeSH KeywordsAdultCell ProliferationChemokines, CCEmbryo ImplantationEndometriumFemaleFrizzled ReceptorsGene Expression ProfilingHeat-Shock ProteinsHedgehog ProteinsHumansKiller Cells, NaturalMenstrual CycleMetallothioneinReceptor, Angiotensin, Type 2Receptors, ProgesteroneTransforming Growth Factor beta2ConceptsLate proliferative phaseMid-proliferative phaseEarly proliferative phaseProliferative phaseNatural killer cell functionHigh expressionTime pointsKiller cell functionHigher serum levelsChemokine ligand 18Angiotensin II receptorsModulation of inflammationProliferative phase endometriumReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionEstrogen-responsive growthGrowth factor β2Metallothionein 2A.Distinct functional subdivisionsUnique gene expression signatureGene expression signaturesEndometrial growthNK cellsSerum levelsEndometrial development
2011
Angiotensin II Stimulates H+-ATPase Activity in Intercalated Cells from Isolated Mouse Connecting Tubules and Cortical Collecting Ducts
Wagner CA, Mohebbi N, Uhlig U, Giebisch GH, Breton S, Brown D, Geibel JP. Angiotensin II Stimulates H+-ATPase Activity in Intercalated Cells from Isolated Mouse Connecting Tubules and Cortical Collecting Ducts. Cellular Physiology And Biochemistry 2011, 28: 513-520. PMID: 22116365, PMCID: PMC3709473, DOI: 10.1159/000335112.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsAnion Transport ProteinsBicarbonatesCell MembraneChloridesColchicineHydrogen-Ion ConcentrationImmunohistochemistryKidney CortexKidney Tubules, CollectingMacrolidesMaleMiceMice, Inbred C57BLReceptors, AngiotensinSaralasinSodiumSulfate TransportersVacuolar Proton-Translocating ATPasesConceptsCNT/CCDAngiotensin IICortical collecting ductsBicarbonate secretionChloride absorptionCollecting ductsType 1 angiotensin II receptorAngiotensin II stimulatesAngiotensin II receptorsAcid-base statusConnecting tubuleATPase activityII receptorsSpecific subtypesNephron segmentsIndependent intracellularAcid extrusionType BSecretionTubulesDuct systemDuctPendrinPresent studyCells
2008
Multi‐scale modeling of neuronal adaptation mediated by angiotensin II in the central regulation of blood pressure
Vadigepalli R, Nikolaev E, Miller G, Ogunnaike B, Gonye G, Kholodenko B, Schwaber J. Multi‐scale modeling of neuronal adaptation mediated by angiotensin II in the central regulation of blood pressure. The FASEB Journal 2008, 22: 756.2-756.2. DOI: 10.1096/fasebj.22.1_supplement.756.2.Peer-Reviewed Original ResearchRelease of norepinephrineAngiotensin II receptorsSynthesis of norepinephrineType 1 activationAP-1PI3K pathwayCardiorespiratory neuronsBlood pressureAngiotensin IIC-Jun activationCardiovascular regulationCNS neuronsLong-term effectsCentral regulationTyrosine hydroxylaseTranscription factor AP-1Rate-limiting enzymeII receptorsKey neurotransmitterNeuronal adaptationFactor AP-1NorepinephrineK pathwayC-fos
1997
Angiotensin II activates the beta 1 isoform of phospholipase C in vascular smooth muscle cells
Schelling J, Nkemere N, Konieczkowski M, Martin K, Dubyak G. Angiotensin II activates the beta 1 isoform of phospholipase C in vascular smooth muscle cells. American Journal Of Physiology 1997, 272: c1558-c1566. PMID: 9176147, DOI: 10.1152/ajpcell.1997.272.5.c1558.Peer-Reviewed Original ResearchConceptsAortic vascular smooth muscle cellsVascular smooth muscle cellsHuman aortic vascular smooth muscle cellsPLC-beta 1Ang IISmooth muscle cellsPLC beta isoformsPLC-beta 1 antibodyRat aortic vascular smooth muscle cellsPermeabilized vascular smooth muscle cellsMuscle cellsGrowth factorPathophysiology of hypertensionAngiotensin II receptorsIP formationReverse transcriptase-polymerase chain reactionPLC-gamma 1 antibodyTranscriptase-polymerase chain reactionPlatelet-derived growth factorCytosolic free Ca2Gamma 1 antibodiesAng II signalsAngiotensin IIAlpha antibodyII receptors
1994
Angiotensin II stimulation of Na-H antiporter activity is cAMP independent in OKP cells
Cano A, Miller RT, Alpern RJ, Preisig PA. Angiotensin II stimulation of Na-H antiporter activity is cAMP independent in OKP cells. American Journal Of Physiology 1994, 266: c1603-c1608. PMID: 8023891, DOI: 10.1152/ajpcell.1994.266.6.c1603.Peer-Reviewed Original ResearchConceptsPertussis toxin-sensitive G proteinToxin-sensitive G proteinNa-H antiporter activityAngiotensin IINa-H antiporterOKP cellsAngiotensin II concentrationAngiotensin II receptorsAbsence of IBMXAngiotensin II stimulationG proteinsCyclic monophosphateProximal tubule apical membraneOpossum kidney cellsConcentration-dependent mannerCAMP-independent mechanismM losartanAcute treatmentAT1 receptorII stimulationPertussis toxinII receptorsProximal tubulesCAMP productionStimulatory effect
1992
Reduced glomerular thromboxane receptor sites and vasoconstrictor responses in diabetic rats
Wilkes B, Kaplan R, Mento P, Aynedjian H, Macica C, Schlondorff D, Bank N. Reduced glomerular thromboxane receptor sites and vasoconstrictor responses in diabetic rats. Kidney International 1992, 41: 992-999. PMID: 1387436, DOI: 10.1038/ki.1992.151.Peer-Reviewed Original ResearchConceptsRenal blood flowGlomerular filtration rateDiabetic ratsThromboxane receptorFiltration rateBlood flowNormal controlsReceptor sitesHigher renal blood flowEuglycemic diabetic ratsHyperglycemic diabetic ratsRenal hemodynamic responseStable thromboxane analogThromboxane synthetase inhibitionUrinary thromboxane excretionInjection of streptozotocinAngiotensin II receptorsThromboxane excretionVasoconstrictor responsesConstrictor responsesDiabetic kidneyEarly diabetesVasoconstrictor receptorsBlood glucoseRats 7
1991
Specific, high-affinity binding sites for angiotensin II on Mycoplasma hyorhinis
Bergwitz C, Madoff S, Abou-Samra A, Ju¨ppner H. Specific, high-affinity binding sites for angiotensin II on Mycoplasma hyorhinis. Biochemical And Biophysical Research Communications 1991, 179: 1391-1399. PMID: 1718269, DOI: 10.1016/0006-291x(91)91727-t.Peer-Reviewed Original ResearchConceptsAngiotensin II receptorsAngiotensin IIII receptorsHigh-affinity binding sitesAngiotensin II bindingOpossum kidney cellsCGP 42112ADuP 753Angiotensin IIIStrains of Mycoplasma hyorhinisAngiotensin IHuman angiotensin IIM. hominisHigh affinityKidney cellsBinding sitesII bindingMycoplasma hyorhinisSpecific bindingReceptorsStrains of M. hominisAntagonist DuP 753Fold decreaseSensitive to bacitracin
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