2021
Circulating cytokines associated with clinical response to systemic therapy in metastatic renal cell carcinoma
Chehrazi-Raffle A, Meza L, Alcantara M, Dizman N, Bergerot P, Salgia N, Hsu J, Ruel N, Salgia S, Malhotra J, Karczewska E, Kortylewski M, Pal S. Circulating cytokines associated with clinical response to systemic therapy in metastatic renal cell carcinoma. Journal For ImmunoTherapy Of Cancer 2021, 9: e002009. PMID: 33688021, PMCID: PMC7944971, DOI: 10.1136/jitc-2020-002009.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factor tyrosine kinase inhibitorMetastatic renal cell carcinomaRenal cell carcinomaImmune checkpoint inhibitorsColony-stimulating factorClinical benefitPlasma cytokinesSystemic therapyCell carcinomaInterleukin-6Prospective correlative studyLines of therapyLow pretreatment levelsGranulocyte colony-stimulating factorGranulocyte-macrophage colony-stimulating factorRCC histologic subtypesMacrophage colony-stimulating factorICI armsICI therapyStable diseaseCheckpoint inhibitorsClinical responsePartial responseComplete responseImmunologic profileDistinct cytokines predict response to immunotherapy and targeted therapy in metastatic renal cell carcinoma (mRCC).
Chehrazi-Raffle A, Meza L, Alcantara M, Salgia N, Dizman N, Bergerot P, Hsu J, Kortylewski M, Pal S. Distinct cytokines predict response to immunotherapy and targeted therapy in metastatic renal cell carcinoma (mRCC). Journal Of Clinical Oncology 2021, 39: 352-352. DOI: 10.1200/jco.2021.39.6_suppl.352.Peer-Reviewed Original ResearchVascular endothelial growth factor tyrosine kinase inhibitorMetastatic renal cell carcinomaImmune checkpoint inhibitorsPlasma cytokinesClinical benefitCommon immune checkpoint inhibitorsICI combination therapyLow pretreatment levelsRenal cell carcinomaEligible patientsICI armsStable diseaseCheckpoint inhibitorsImmunologic profilePartial responseSystemic therapyComplete responseProspective studyIL-1raCell carcinomaCombination therapyIL-6Pretreatment levelsDistinct cytokinesG-CSF
2020
Bleeding with vascular endothelial growth factor tyrosine kinase inhibitor: A network meta-analysis
Das A, Mahapatra S, Bandyopadhyay D, Samanta S, Chakraborty S, Philpotts LL, Jahangir E, Roy B. Bleeding with vascular endothelial growth factor tyrosine kinase inhibitor: A network meta-analysis. Critical Reviews In Oncology/Hematology 2020, 157: 103186. PMID: 33309571, DOI: 10.1016/j.critrevonc.2020.103186.Peer-Reviewed Original ResearchConceptsTyrosine kinase inhibitorsHemorrhagic eventsVEGFR-TKICancer patientsOdds ratioVascular endothelial growth factor tyrosine kinase inhibitorVascular endothelial growth factor receptor tyrosine kinase inhibitorsGrowth factor receptor tyrosine kinase inhibitorsReceptor tyrosine kinase inhibitorsKinase inhibitorsHigh-grade bleedingSide effect profileStandard chemotherapeutic regimenFirst-choice treatmentConfidence intervalsRandom-effects modelTypes of cancerVEGFR-TKIsChemotherapeutic regimenPrimary outcomeClinical trialsHigh riskPlaceboComparative riskPatients
2019
Targeted Therapy and Immunotherapy: Effect of Body Mass Index on Clinical Outcomes in Patients Diagnosed with Metastatic Renal Cell Carcinoma
Bergerot P, Bergerot C, Philip E, Meza L, Dizman N, Hsu J, Pal S. Targeted Therapy and Immunotherapy: Effect of Body Mass Index on Clinical Outcomes in Patients Diagnosed with Metastatic Renal Cell Carcinoma. Kidney Cancer 2019, 3: 63-70. DOI: 10.3233/kca-180047.Peer-Reviewed Original ResearchVascular endothelial growth factor tyrosine kinase inhibitorHigher Body Mass IndexBody mass indexLower body mass indexMedian overall survivalOverall survivalMass indexMetastatic renal cell carcinoma patientsMetastatic renal cell carcinomaEffect of BMIRenal cell carcinoma patientsImproved overall survivalCell carcinoma patientsBetter overall survivalKaplan-Meier methodContext of immunotherapyRenal cell carcinomaPatients 66Median OSCarcinoma patientsClinical outcomesHigher BMIRetrospective studyCell carcinomaClinical variables
2018
Neuropathy as an adverse effect of vascular endothelial growth factor tyrosine kinase inhibitors, a meta-analysis of randomized clinical trials (P6.098)
Roy B, Das A, Maity A, Gupta A, Bandypadhyay D. Neuropathy as an adverse effect of vascular endothelial growth factor tyrosine kinase inhibitors, a meta-analysis of randomized clinical trials (P6.098). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p6.098.Peer-Reviewed Original ResearchVascular endothelial growth factor tyrosine kinase inhibitorMeta-analysis of randomized clinical trialsTyrosine kinase inhibitorsRandomized clinical trialsKinase inhibitorsClinical trialsMeta-analysisAdverse effects
2012
Cytoreductive nephrectomy for metastatic renal cell carcinoma in the era of targeted therapy in the United States: a SEER analysis
Tsao C, Small A, Kates M, Moshier E, Wisnivesky J, Gartrell B, Sonpavde G, Godbold J, Palese M, Hall S, Oh W, Galsky M. Cytoreductive nephrectomy for metastatic renal cell carcinoma in the era of targeted therapy in the United States: a SEER analysis. World Journal Of Urology 2012, 31: 1535-1539. PMID: 23223962, PMCID: PMC4744480, DOI: 10.1007/s00345-012-1001-3.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaVEGFR-TKIsRenal cell carcinomaLogistic regression analysisCytoreductive nephrectomyCell carcinomaTreatment of metastatic renal cell carcinomaVascular endothelial growth factor tyrosine kinase inhibitorEra of targeted therapyMultivariate logistic regression analysisEnd Results registryPhase III trialsTyrosine kinase inhibitorsLevel 1 evidenceAssociated with decreased useSEER analysisRegression analysisMethodsThe SurveillanceIII trialsTreatment eraTreatment modalitiesOlder patientsPatient characteristicsKinase inhibitorsRandomized trials
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply