2025
Use of AMD3100 for Bone Marrow Derived Mesenchymal Stem Cells Mobilization in the Treatment of Murine Asherman’s Syndrome
Flores V, Delis P, Mamillapalli R, Taylor H. Use of AMD3100 for Bone Marrow Derived Mesenchymal Stem Cells Mobilization in the Treatment of Murine Asherman’s Syndrome. F&S Science 2025 PMID: 40818715, DOI: 10.1016/j.xfss.2025.08.003.Peer-Reviewed Original ResearchAsherman's syndromePreterm ruptureAS inductionMurine modelProgenitor cellsMesenchymal stem cell mobilizationMice treated with AMD3100Preterm rupture of membranesAMD3100-treated miceRupture of membranesOptimal timingStem cell mobilizationBone marrow transplantationTreatment groupsLevels of CXCL12Source of progenitor cellsRecurrent pregnancy lossEndometrial progenitor cellsBMD-MSCsLikelihood of pregnancyHysteroscopic adhesiolysisPlacental abruptionUterine repairSevere ASMarrow transplantation
2021
Characterization of Bone Marrow Progenitor Cell Uterine Engraftment and Transdifferentiation
Mamillapalli R, Mutlu L, Taylor HS. Characterization of Bone Marrow Progenitor Cell Uterine Engraftment and Transdifferentiation. Reproductive Sciences 2021, 29: 2382-2390. PMID: 34515983, DOI: 10.1007/s43032-021-00738-5.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsRecipient miceBone marrow-derived cellsProgenitor cellsBone marrow transplantMarrow-derived cellsMarrow-derived stem cellsSpecific uterine cell typesBone marrow-derived progenitorsMarrow-derived progenitorsUterine cell typesUpregulation of markersCell surface markersStem cellsSpecific stem cell markersStem cell markersCell typesUterine repairMarrow transplantStem cell componentUterine tissueMurine modelMaintenance of fertilityDifferentiation of BMSCsCell markers
2017
CXCL12 Promotes Stem Cell Recruitment and Uterine Repair after Injury in Asherman’s Syndrome
Ersoy G, Zolbin MM, Cosar E, Moridi I, Mamillapalli R, Taylor HS. CXCL12 Promotes Stem Cell Recruitment and Uterine Repair after Injury in Asherman’s Syndrome. Molecular Therapy — Methods & Clinical Development 2017, 4: 169-177. PMID: 28345002, PMCID: PMC5363300, DOI: 10.1016/j.omtm.2017.01.001.Peer-Reviewed Original ResearchAsherman's syndromeUterine repairBone marrow-derived mesenchymal stem cellsStem cell recruitmentCell recruitmentStem cell supplementationAdverse pregnancy outcomesTreatment of infertilityMarrow-derived mesenchymal stem cellsStem cell engraftmentCXCL12 administrationUterine fibrosisPregnancy outcomesUterine disordersUterine injuryReceptor antagonistReceptor agonistFunctional improvementMurine modelCXCL12 treatmentCell engraftmentLitter sizeCXCL12 productionMesenchymal stem cellsSyndrome
2014
Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome
Alawadhi F, Du H, Cakmak H, Taylor HS. Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome. PLOS ONE 2014, 9: e96662. PMID: 24819371, PMCID: PMC4018329, DOI: 10.1371/journal.pone.0096662.Peer-Reviewed Original ResearchConceptsAsherman's syndromeMurine modelBone marrowIschemia/reperfusion injurySyndrome modelNon-transplanted groupStem cell transplantationUninjured control groupPotential novel treatmentTransplant groupUterine repairIntrauterine adhesionsReperfusion injuryCell transplantationNormal endometriumUterine injuryStem cell recruitmentEndometrial cellsUninjured controlsCell recruitmentNovel treatmentsUterine hornControl groupEndometriumSyndrome
2012
Ischemia/Reperfusion Injury Promotes and Granulocyte-Colony Stimulating Factor Inhibits Migration of Bone Marrow-Derived Stem Cells to Endometrium
Du H, Naqvi H, Taylor HS. Ischemia/Reperfusion Injury Promotes and Granulocyte-Colony Stimulating Factor Inhibits Migration of Bone Marrow-Derived Stem Cells to Endometrium. Stem Cells And Development 2012, 21: 3324-3331. PMID: 22897736, PMCID: PMC3516416, DOI: 10.1089/scd.2011.0193.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsBone Marrow TransplantationCell DifferentiationCell MovementCell ProliferationEndometriumEstrous CycleFemaleGranulocyte Colony-Stimulating FactorHematopoietic Stem Cell MobilizationHematopoietic Stem CellsHumansMaleMesenchymal Stem CellsMiceMice, Inbred C57BLRegenerationReperfusion InjuryStem CellsUterusConceptsGranulocyte-colony stimulating factorSex steroidsMesenchymal stem cellsUterine repairUterine injuryBone marrowEstrous cycleIschemia/reperfusion injuryStem cellsBM-derived cellsG-CSF treatmentBM transplantsReperfusion injuryBM engraftmentIschemic injuryStem cell recruitmentMenstrual cycleMSC engraftmentCell recruitmentEndometriumInhibits migrationInjuryHematopoietic stem cellsStimulating factorUterus
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