2021
Disordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons and aberrant Nav1.8 expression
Cleary C, James S, Maher B, Mulkey D. Disordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons and aberrant Nav1.8 expression. Nature Communications 2021, 12: 5962. PMID: 34645823, PMCID: PMC8514575, DOI: 10.1038/s41467-021-26263-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic Helix-Loop-Helix Transcription FactorsBenzimidazolesBrain StemCarbon DioxideDisease Models, AnimalFaciesGene Expression RegulationHaploinsufficiencyHomeodomain ProteinsHumansHyperventilationIntellectual DisabilityMaleMiceMice, KnockoutNAV1.8 Voltage-Gated Sodium ChannelNeuronsPsychomotor PerformancePyrazolesRespirationTranscription Factor 4Transcription FactorsConceptsPitt-Hopkins syndromeParafacial neuronsBreathing problemsEpisodes of hyperventilationFunction of neuronsNav1.8 expressionPTH patientsRetrotrapezoid nucleusNav1.8 channelsTranscription factor 4Behavioral deficitsMouse modelRespiratory functionBehavioral abnormalitiesTherapeutic potentialSyndrome modelDevelopmental delaySelective lossNeuronsIntellectual disabilityFactor 4Functional haploinsufficiencyBehavioral levelNav1.8Apnea
2017
Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model
Chung L, Bey AL, Towers AJ, Cao X, Kim IH, Jiang YH. Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model. Neurobiology Of Disease 2017, 110: 12-19. PMID: 29097328, PMCID: PMC5903876, DOI: 10.1016/j.nbd.2017.10.016.Peer-Reviewed Original ResearchConceptsEpileptiform activityMouse modelAngelman syndrome modelFragile X syndrome mouse modelLower seizure thresholdSyndrome mouse modelNeural mechanismsAngelman syndromeSeizure thresholdSynaptic dysfunctionAudiogenic seizuresExcitatory neurotransmissionLocal circuitsSyndrome modelSeizuresUBE3ADrug screeningFXS modelsHyperexcitabilitySupDysfunctionEpilepsyNeurotransmissionSyndromeDissection
2014
Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome
Alawadhi F, Du H, Cakmak H, Taylor HS. Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome. PLOS ONE 2014, 9: e96662. PMID: 24819371, PMCID: PMC4018329, DOI: 10.1371/journal.pone.0096662.Peer-Reviewed Original ResearchConceptsAsherman's syndromeMurine modelBone marrowIschemia/reperfusion injurySyndrome modelNon-transplanted groupStem cell transplantationUninjured control groupPotential novel treatmentTransplant groupUterine repairIntrauterine adhesionsReperfusion injuryCell transplantationNormal endometriumUterine injuryStem cell recruitmentEndometrial cellsUninjured controlsCell recruitmentNovel treatmentsUterine hornControl groupEndometriumSyndrome
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply