2025
Urinary metabolites in association with kidney cancer risk
Al-Sayegh T, Song S, Lipworth L, Cai H, Lan Q, Gao Y, Rothman N, Cai Q, Zheng W, Shu X. Urinary metabolites in association with kidney cancer risk. Carcinogenesis 2025, 46: bgaf029. PMID: 40576378, PMCID: PMC12277705, DOI: 10.1093/carcin/bgaf029.Peer-Reviewed Original ResearchConceptsKidney cancer riskUrinary metabolitesAssociated with kidney cancerCancer riskMetabolomics studiesAssociated with kidney cancer riskKidney cancerCase-control studyMen's Health StudyKidney cancer casesKidney cancer incidenceUrine sample collectionUrine metabolitesCancer casesCancer associationCancer incidenceUrinary samplesMatched ControlsCancerLogistic regressionShanghai WomeKidneyCancer diagnosisHealth StudyUrine
2018
Phthalate Exposure from Drinking Water in Romanian Adolescents
Sulentic RO, Dumitrascu I, Deziel NC, Gurzau AE. Phthalate Exposure from Drinking Water in Romanian Adolescents. International Journal Of Environmental Research And Public Health 2018, 15: 2109. PMID: 30257478, PMCID: PMC6209931, DOI: 10.3390/ijerph15102109.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolite concentrationsPhthalate metabolite concentrationsChronic low-level exposureAdverse health outcomesLow-level exposureDifferent exposure measuresPhthalate exposurePhthalate metabolitesMunicipal drinking waterUrinary metabolitesHealth outcomesSignificant associationHigher maximum concentrationUrine samplesConsumer product usePotential health risksAdolescent groupExposure sourcesExposure measuresDrinking waterExposure determinantsProduct useMetabolite concentrations
2017
Metabolomics reveals new metabolic perturbations in children with type 1 diabetes
Galderisi A, Pirillo P, Moret V, Stocchero M, Gucciardi A, Perilongo G, Moretti C, Monciotti C, Giordano G, Baraldi E. Metabolomics reveals new metabolic perturbations in children with type 1 diabetes. Pediatric Diabetes 2017, 19: 59-67. PMID: 28401628, DOI: 10.1111/pedi.12524.Peer-Reviewed Original ResearchConceptsBody mass indexType 1 diabetesHealthy controlsPubertal statusExcess of cortisolMetabolome of childrenPediatric diabetes clinicMacrovascular complicationsDiabetes clinicDisease durationNeuronal damagePediatric patientsClinical featuresMass indexCase groupTryptophan catabolitesHealthy peersUrinary metabolitesUrinary samplesBacterial productsT1DUntargeted metabolomics approachMetabolic perturbationsDiabetesPatients
2016
Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women
López-Carrillo L, Gamboa-Loira B, Becerra W, Hernández-Alcaraz C, Hernández-Ramírez RU, Gandolfi AJ, Franco-Marina F, Cebrián ME. Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women. Environmental Research 2016, 151: 445-450. PMID: 27565879, PMCID: PMC5457700, DOI: 10.1016/j.envres.2016.08.015.Peer-Reviewed Original ResearchConceptsMetabolism of iAsDietary micronutrient intakeFood frequency questionnaireMagnitude of exposureFrequency questionnaireDietary interventionDiet contributesDietary factorsDietary intakeMicronutrient intakeUrinary metabolitesVitamin B12Mexican womenInterindividual variationIntakeFurther studiesHigh-performance liquid chromatographyConsequent riskWomenPerformance liquid chromatographyMetabolismIAArsenic metabolismInorganic arsenicExposure
2015
Statistical methods for modeling repeated measures of maternal environmental exposure biomarkers during pregnancy in association with preterm birth
Chen Y, Ferguson K, Meeker J, McElrath T, Mukherjee B. Statistical methods for modeling repeated measures of maternal environmental exposure biomarkers during pregnancy in association with preterm birth. Environmental Health 2015, 14: 9. PMID: 25619201, PMCID: PMC4417225, DOI: 10.1186/1476-069x-14-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBiomarkersBostonCase-Control StudiesCross-Sectional StudiesData Interpretation, StatisticalEnvironmental ExposureFemaleHazardous SubstancesHumansInfant, NewbornMaternal ExposureMiddle AgedModels, StatisticalPhthalic AcidsPregnancyPremature BirthSocioeconomic FactorsYoung AdultConceptsPreterm birthEnvironmental chemical exposuresMeasures of urinary phthalate metabolitesNested Case-Control StudyCross-sectional analysisAverage exposureMeasures of exposureCase-control studyUrinary phthalate metabolitesModel repeated measuresEpidemiological research projectsLongitudinal exposureRepeated measuresPremature birthPretermEnvironmental exposure biomarkersExposure measurementsUrinary metabolitesMaternal factorsPhthalate metabolitesPregnancyStudy of phthalatesLongitudinal predictorsChemical exposureBirth
2013
Dietary Protein-Induced Increases in Urinary Calcium Are Accompanied by Similar Increases in Urinary Nitrogen and Urinary Urea: A Controlled Clinical Trial
Bihuniak JD, Simpson CA, Sullivan RR, Caseria DM, Kerstetter JE, Insogna KL. Dietary Protein-Induced Increases in Urinary Calcium Are Accompanied by Similar Increases in Urinary Nitrogen and Urinary Urea: A Controlled Clinical Trial. Journal Of The Academy Of Nutrition And Dietetics 2013, 113: 447-451. PMID: 23438496, PMCID: PMC5868414, DOI: 10.1016/j.jand.2012.11.002.Peer-Reviewed Original ResearchConceptsBone turnover markersDietary protein intakeUrinary creatinineUrinary calciumProtein intakeUrinary ureaTurnover markersUrinary nitrogenNutrition intervention trialMaltodextrin controlPostmenopausal womenIntervention trialsClinical trialsUrinary metabolitesCreatinineDay 0Whey supplementationWhey supplementsIntakeSample t-testSimilar increaseTrialsT-testSupplementationMarkers
2012
Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics
Johnson CH, Slanař O, Krausz KW, Kang DW, Patterson AD, Kim JH, Luecke H, Gonzalez FJ, Idle JR. Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics. American Journal Of Clinical Nutrition 2012, 96: 818-830. PMID: 22952181, PMCID: PMC3441109, DOI: 10.3945/ajcn.112.042929.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultalpha-TocopherolAmino AcidsAnimalsCholesterolChromansChromatography, High Pressure LiquidFemaleGlucuronidesHumansLiverMaleMetabolomicsMiceMice, Inbred C57BLMolecular StructureSpecies SpecificitySpectrometry, Mass, Electrospray IonizationTaurineVitamin E DeficiencyYoung AdultConceptsVitamin EUrinary metabolitesMass spectrometry-based metabolomicsNovel urinary metaboliteLiver fatty acidLiver cholesterolC57BL/6 miceChronic diseasesClinical trialsΑ-tocopherolMouse modelNovel metabolitesVitamin E.Human volunteersDietary supplementsUltraperformance liquid chromatographyMiceSerum samplesInterindividual variationLiver samplesDosingSerumUrineFatty acidsMetabolitesUrinary Metabolic Phenotyping the slc26a6 (Chloride–Oxalate Exchanger) Null Mouse Model
Garcia-Perez I, Villaseñor A, Wijeyesekera A, Posma JM, Jiang Z, Stamler J, Aronson P, Unwin R, Barbas C, Elliott P, Nicholson J, Holmes E. Urinary Metabolic Phenotyping the slc26a6 (Chloride–Oxalate Exchanger) Null Mouse Model. Journal Of Proteome Research 2012, 11: 4425-4435. PMID: 22594923, PMCID: PMC4028149, DOI: 10.1021/pr2012544.Peer-Reviewed Original ResearchConceptsRenal stone diseaseStone diseaseNull miceUrinary metabolic signaturesBlood pressure controlWild-type miceNull mouse modelRenal stone formationRenal proximal tubulesUrinary metabolicUrinary metabolomeClear metabolic differentiationSodium homeostasisRenal stonesType miceMouse modelUrinary metabolitesOxalate balanceUrinary profilesProximal tubulesPressure controlStone formationExchanger SLC26A6Metabolic signaturesPathological processes
2011
Novel Biomarkers of Organophosphate Exposure
Satoh T, Inayat‐Hussain S, Kamijima M, Ueyama J. Novel Biomarkers of Organophosphate Exposure. 2011, 289-302. DOI: 10.1002/9780470640500.ch20.Peer-Reviewed Original Research
2008
Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography–mass spectrometry
Kim KM, Henderson GN, Frye RF, Galloway CD, Brown NJ, Segal MS, Imaram W, Angerhofer A, Johnson RJ. Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography–mass spectrometry. Journal Of Chromatography B 2008, 877: 65-70. PMID: 19081307, PMCID: PMC2684329, DOI: 10.1016/j.jchromb.2008.11.029.Peer-Reviewed Original ResearchConceptsUric acidUrinary metabolitesOxidative stressSelected-reaction monitoringUrinary creatinineNormal individualsNitric oxideUrine samplesLiquid chromatography-mass spectrometryBiological samplesPositive ion modeTandem mass spectrometry methodHigh-performance liquid chromatographyMass spectrometry methodChromatography-mass spectrometryUrineInter-day precisionMetabolitesUrinary allantoinIon modeLC-MS/MS analysisHuman urineGradient HPLCMost mammalsSpectrometry method
1999
Fluid Intake and the Risk of Bladder Cancer in Men
Michaud D, Spiegelman D, Clinton S, Rimm E, Curhan G, Willett W, Giovannucci E. Fluid Intake and the Risk of Bladder Cancer in Men. New England Journal Of Medicine 1999, 340: 1390-1397. PMID: 10228189, DOI: 10.1056/nejm199905063401803.Peer-Reviewed Original ResearchConceptsTotal fluid intakeTotal daily fluid intakeDaily fluid intakeBladder cancerFluid intakeMultivariate relative riskFood frequency questionnaireFrequency of voidingHigh fluid intakeLogistic regression analysisProspective Health ProfessionalsFrequency of urinationFrequency of consumptionDecreased riskHighest quintileType of beverageLowest quintileRisk factorsRelative riskLower riskUrinary metabolitesHealth professionalsCancerIntakeRisk
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