2018
Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses
Cañadas I, Thummalapalli R, Kim J, Kitajima S, Jenkins R, Christensen C, Campisi M, Kuang Y, Zhang Y, Gjini E, Zhang G, Tian T, Sen D, Miao D, Imamura Y, Thai T, Piel B, Terai H, Aref A, Hagan T, Koyama S, Watanabe M, Baba H, Adeni A, Lydon C, Tamayo P, Wei Z, Herlyn M, Barbie T, Uppaluri R, Sholl L, Sicinska E, Sands J, Rodig S, Wong K, Paweletz C, Watanabe H, Barbie D. Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses. Nature Medicine 2018, 24: 1143-1150. PMID: 30038220, PMCID: PMC6082722, DOI: 10.1038/s41591-018-0116-5.Peer-Reviewed Original ResearchConceptsInnate immune signalingSmall cell lung cancerEndogenous retrovirusesCell lung cancerPro-tumorigenic cytokinesImmune signalingAnalysis of cell linesCancer immunotherapyMesenchymal cell stateIFN-gTumor subpopulationsLung cancerLong terminal repeatHuman tumorsSPARC expressionMesenchymal markersTumorBi-directional transcriptionChromatin-modifying enzymesSTAT1 SignalingCell linesCancerInnate immunityInducible SPARCS expressionGene promoter
2012
Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
Celià-Terrassa T, Meca-Cortés Ó, Mateo F, de Paz A, Rubio N, Arnal-Estapé A, Ell B, Bermudo R, Díaz A, Guerra-Rebollo M, Lozano J, Estarás C, Ulloa C, ρlvarez-Simón D, Milà J, Vilella R, Paciucci R, Martínez-Balbás M, de Herreros A, Gomis R, Kang Y, Blanco J, Fernández P, Thomson T. Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. Journal Of Clinical Investigation 2012, 122: 1849-1868. PMID: 22505459, PMCID: PMC3366719, DOI: 10.1172/jci59218.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, DifferentiationCadherinsCell Line, TumorCell MovementCell ShapeCoculture TechniquesEpithelial CellsEpithelial-Mesenchymal TransitionGene Expression ProfilingGene Regulatory NetworksHomeodomain ProteinsHumansMaleMiceMice, Inbred NODMice, SCIDNeoplasm InvasivenessNeoplasm MetastasisNeoplasm StagingNeoplasm TransplantationProstatic NeoplasmsRepressor ProteinsSnail Family Transcription FactorsSpheroids, CellularTranscription FactorsTwist-Related Protein 1Urinary Bladder NeoplasmsZinc Finger E-box-Binding Homeobox 1ConceptsEpithelial-mesenchymal transitionDistant metastasisSelf-RenewalGene programTumor-initiating cellsEpithelial-mesenchymal transition programProstate cancer cellsIn vitro invasionPrimary implantation sitesHuman cellular modelsMetastatic populationBladder cancerTumor subpopulationsLocal invasionMesenchymal-likeEpithelial featuresMetastatic phenotypeNeoplastic cellsMalignant progressionImplantation sitesMesenchymal traitsEMT factorsCancer cellsMesenchymal genesIn vivo
2004
X-TileA New Bio-Informatics Tool for Biomarker Assessment and Outcome-Based Cut-Point Optimization
Camp RL, Dolled-Filhart M, Rimm DL. X-TileA New Bio-Informatics Tool for Biomarker Assessment and Outcome-Based Cut-Point Optimization. Clinical Cancer Research 2004, 10: 7252-7259. PMID: 15534099, DOI: 10.1158/1078-0432.ccr-04-0713.Peer-Reviewed Original Research
1997
Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice
Feldman B, Reid T, Cleary M. Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice. Oncogene 1997, 15: 2735-2742. PMID: 9401000, DOI: 10.1038/sj.onc.1201670.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionDisease ProgressionDNA Transposable ElementsGene RearrangementHomeodomain ProteinsLeukemia Virus, MurineLymphomaMiceMice, TransgenicMutagenesisNeoplasm TransplantationOncogene Proteins, FusionProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-pim-1RetroviridaeThymus NeoplasmsTransgenesConceptsTransgenic miceMonths of ageE2A-PBX1High-grade T-cell lymphomaE2A-PBX1 transgenic miceT-lineage lymphomasAssociated with tumor progressionT-cell lymphomaDevelopment of lymphomaSite of involvementRetroviral insertional mutagenesisLength of survivalActivated c-MycThymic lymphomasSyngeneic recipientsMonoclonal lymphomaTumor subpopulationsLymphomaTumor progressionRetroviral infectionGenetic eventsNegative cellsLymphomagenesisC-MycRetroviral insertion
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