2025
Triple negative breast cancer cells acquire lymphocyte proteins and genomic DNA during trogocytosis with T cells
Sivakoses A, Marcarian H, Arias A, Lam A, Ihedioha O, Santamaria-Barria J, Gurtner G, Bothwell A. Triple negative breast cancer cells acquire lymphocyte proteins and genomic DNA during trogocytosis with T cells. PeerJ 2025, 13: e19236. PMID: 40183054, PMCID: PMC11967428, DOI: 10.7717/peerj.19236.Peer-Reviewed Original ResearchConceptsTriple negative breast cancerTriple negative breast cancer cellsT cellsCancer cellsTumor cell expressionNegative breast cancer cellsNegative breast cancerGenomic DNABreast cancer cellsCluster of differentiationSpecific proteinsT cell-specific proteinsLymphoid markersBreast cancerDonor cellsCell expressionCD45Immune detectionFlow cytometryPatient samplesTrogocytosisCD45RACo-CultureImmunofluorescence imagingLymphocyte protein
2019
Quantitative MHC II protein expression levels in tumor epithelium to predict response to the PD1 inhibitor pembrolizumab in the I-SPY 2 Trial.
Wulfkuhle J, Yau C, Wolf D, Gallagher R, Brown Swigart L, Hirst G, Campbell M, Nanda R, Liu M, Pusztai L, Esserman L, Berry D, van 't Veer L, Petricoin E. Quantitative MHC II protein expression levels in tumor epithelium to predict response to the PD1 inhibitor pembrolizumab in the I-SPY 2 Trial. Journal Of Clinical Oncology 2019, 37: 2631-2631. DOI: 10.1200/jco.2019.37.15_suppl.2631.Peer-Reviewed Original ResearchI-SPY 2 TRIALImmune checkpoint inhibitorsCheckpoint inhibitorsTumor epitheliumPD1 inhibitor pembrolizumabTumor antigen presentationHER2-negative subtypeMHC-II expressionTumor cell expressionPredictors of responseWilcoxon rank sum testPositive associationRank sum testProtein expression levelsImmune activationControl armAntigen presentationResponse predictorsHR subgroupsB cellsCell expressionPatientsSum testProtein expressionTumors
2015
Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer
Patel M, Jacobson B, Ji Y, Drees J, Tang S, Xiong K, Wang H, Prigge J, Dash A, Kratzke A, Mesev E, Etchison R, Federspiel M, Russell S, Kratzke R. Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer. Oncotarget 2015, 6: 33165-33177. PMID: 26431376, PMCID: PMC4741756, DOI: 10.18632/oncotarget.5320.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerCell lung cancerVesicular stomatitis virusVSV-GFPIntratumoral injectionT cellsLung cancerTumor-infiltrating regulatory T cellsIncreased CD8+ T cellsExpression of PDL-1Promote antitumor immune responsesModel of non-small cell lung cancerMurine models of non-small cell lung cancerCD8+ T cellsNon-small cell lung cancer cell linesSystemic antitumor immunityTumor cell expressionAntitumor immune responseRegulatory T cellsSyngeneic murine modelNon-small cell lung cancer cellsNude mouse xenograftsTreated in vitroExpressing green fluorescent proteinAntitumor immunity
1997
Effect of Canarypox Virus (ALVAC)-Mediated Cytokine Expression on Murine Prostate Tumor Growth
Kawakita M, Rao G, Ritchey J, Ornstein D, Hudson M, Harmon T, Ratliff T, Humphrey P, Tartaglia J, Paoletti E. Effect of Canarypox Virus (ALVAC)-Mediated Cytokine Expression on Murine Prostate Tumor Growth. Journal Of The National Cancer Institute 1997, 89: 428-436. PMID: 9091644, DOI: 10.1093/jnci/89.6.428.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvipoxvirusB7-1 AntigenCytokinesDisease Models, AnimalFlow CytometryGene Expression Regulation, NeoplasticGene Expression Regulation, ViralGene Transfer TechniquesGenetic VectorsImmunotherapyInterferon-gammaInterleukin-2MaleMiceMice, Inbred C57BLMice, SCIDProstatic NeoplasmsTime FactorsTumor Necrosis Factor-alphaConceptsRM-1 cellsTumor cell expressionMouse prostate cancer cellsIL-2TNF-alphaC57BL/6 miceProstate cancer cellsTumor growthCell expressionTumor sizeB7-1Gene product expressionCo-stimulatory molecules B7-1Canarypox virusCytotoxic T lymphocyte activityKaplan-Meier survival methodMeasurable tumor sizeNonspecific antitumor activitySubsequent tumor challengeT lymphocyte activityCancer cellsCytotoxic T cellsInfected cellsProstate tumor growthMouse prostate tumor model
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