Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer
Patel M, Jacobson B, Ji Y, Drees J, Tang S, Xiong K, Wang H, Prigge J, Dash A, Kratzke A, Mesev E, Etchison R, Federspiel M, Russell S, Kratzke R. Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer. Oncotarget 2015, 6: 33165-33177. PMID: 26431376, PMCID: PMC4741756, DOI: 10.18632/oncotarget.5320.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerCell lung cancerVesicular stomatitis virusVSV-GFPIntratumoral injectionT cellsLung cancerTumor-infiltrating regulatory T cellsIncreased CD8+ T cellsExpression of PDL-1Promote antitumor immune responsesModel of non-small cell lung cancerMurine models of non-small cell lung cancerCD8+ T cellsNon-small cell lung cancer cell linesSystemic antitumor immunityTumor cell expressionAntitumor immune responseRegulatory T cellsSyngeneic murine modelNon-small cell lung cancer cellsNude mouse xenograftsTreated in vitroExpressing green fluorescent proteinAntitumor immunity
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