The Collecting Duct Is the Major Source of Prorenin in Diabetes
Kang J, Toma I, Sipos A, Meer E, Vargas S, Peti-Peterdi J. The Collecting Duct Is the Major Source of Prorenin in Diabetes. Hypertension 2008, 51: 1597-1604. PMID: 18413493, PMCID: PMC2398652, DOI: 10.1161/hypertensionaha.107.107268.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAngiotensin II Type 1 Receptor BlockersAnimalsCell DivisionCells, CulturedDiabetes Mellitus, ExperimentalDiabetic NephropathiesDisease Models, AnimalHypertension, RenalImidazolesImmunohistochemistryJuxtaglomerular ApparatusKidney Tubules, CollectingMicroscopy, FluorescenceQuinacrineRatsRats, WistarReninTetrazolesTrypsinVasoconstrictor AgentsConceptsCD reninRenin activityJuxtaglomerular apparatusAng II type 1 receptor blockadeType 1 receptor blockadeRenin-Ang systemAng II activityAng II treatmentCD cell lineRenal tubular epitheliumMunich-Wistar ratsHigh prorenin levelsVivo multiphoton microscopyJuxtaglomerular reninProrenin contentReceptor blockadeDiabetes mellitusAng IIProrenin levelsAngiotensin IIRenin contentRat modelRenin assaysII treatmentTubular epithelium
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