2021
Insulin Pump Therapy
Doyle E, Cengiz E, Tamborlane W. Insulin Pump Therapy. Contemporary Endocrinology 2021, 55-64. DOI: 10.1007/978-3-030-64133-7_6.Peer-Reviewed Original Research
2020
MON-635 FDXR Regulates Iron Metabolism and Glucose Metabolism in Liver
Sakuma I, Yokoyama M, Yamagata K, Hashimoto N, Nakayama A, Shulman G, Tanaka T. MON-635 FDXR Regulates Iron Metabolism and Glucose Metabolism in Liver. Journal Of The Endocrine Society 2020, 4: mon-635. PMCID: PMC7207756, DOI: 10.1210/jendso/bvaa046.1557.Peer-Reviewed Original ResearchNon-alcoholic fatty liver diseaseForkhead box protein O1Iron metabolismFoxO1 nuclear exclusionOxidative stressFatty liver diseaseSerum ferritin levelsMouse liverHigh-fat dietType 2 diabetesPathogenesis of diabetesNovel therapeutic targetIron regulatory genesHepatic iron contentTreatment of diabetesHepG2 cellsBox protein O1Glucose intoleranceMost patientsFerritin levelsLiver diseaseClinical studiesGluconeogenesis activationFDXR expressionGlucose metabolism
2019
Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes
Casey B, Rice M, Landon M, Varner M, Reddy U, Wapner R, Rouse D, Biggio J, Thorp J, Chien E, Saade G, Peaceman A, Blackwell S, Van Dorsten J. Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes. American Journal Of Perinatology 2019, 37: 475-482. PMID: 30866027, PMCID: PMC6744360, DOI: 10.1055/s-0039-1681058.Peer-Reviewed Original ResearchConceptsMild gestational diabetes mellitusGestational diabetes mellitusBody mass indexMetabolic syndromeIndex pregnancyTreatment of womenSubsequent diabetesLong-term maternal outcomesMaternal body mass indexOral glucose tolerance testMild gestational diabetesFrequency of diabetesHomeostasis model assessmentGlucose tolerance testRisk of diabetesTreatment of diabetesEffect of treatmentRace/ethnicityGestational diabetesLipid panelMaternal outcomesBlood pressureDiabetes mellitusMedical therapyNutritional counseling
2016
The anti-hyperglycemic efficacy of a lipid-lowering drug Daming capsule and the underlying signaling mechanisms in a rat model of diabetes mellitus
Zhang Y, Li X, Li J, Zhang Q, Chen X, Liu X, Zhang Y, Zhang H, Yang H, Hu Y, Wu X, Li X, Ju J, Yang B. The anti-hyperglycemic efficacy of a lipid-lowering drug Daming capsule and the underlying signaling mechanisms in a rat model of diabetes mellitus. Scientific Reports 2016, 6: 34284. PMID: 27721485, PMCID: PMC5056381, DOI: 10.1038/srep34284.Peer-Reviewed Original ResearchConceptsDaming capsuleGLP-1Diabetes mellitusRat modelDiabetic ratsRat model of diabetes mellitusModel of diabetes mellitusRegulatory pathwaysClinical treatmentLipid-lowering drugsSecretion of GLP-1Expression of TCF7L2DM ratsClinical treatment of diabetesGIP secretionBlood lipidsTreatment of diabetesAnti-hyperglycemic effectBlood glucose homeostasisMetabolic disordersRatsGlucose levelsTherapeutic drugsSignaling pathwayGlucose homeostasis
2014
Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks
Strittmatter SM. Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks. Nature Medicine 2014, 20: 590-591. PMID: 24901567, PMCID: PMC4371131, DOI: 10.1038/nm.3595.Peer-Reviewed Original Research
2006
Performing a Cure for Schizophrenia: Insulin Coma Therapy on the Wards
Doroshow DB. Performing a Cure for Schizophrenia: Insulin Coma Therapy on the Wards. Journal Of The History Of Medicine And Allied Sciences 2006, 62: 213-243. PMID: 17105748, DOI: 10.1093/jhmas/jrl044.Peer-Reviewed Original ResearchConceptsInsulin coma therapyComa therapyInsulin unitsMental illnessTreatment of diabetesIntractable patientsRisk assessment testsEfficacious treatmentSide effectsSomatic therapiesTherapyMental hospitalsMiracle drugTreatmentMainstream medicineIllnessMedical doctorsPsychiatristsSchizophreniaBiological psychiatryModern biological psychiatryPsychiatryComplicationsPatientsDiabetes
2005
Treatment of diabetes in the elderly
Sakharova OV, Inzucchi SE. Treatment of diabetes in the elderly. Postgraduate Medicine 2005, 118: 19-29. PMID: 16329527, DOI: 10.3810/pgm.2005.11.1684.Peer-Reviewed Original ResearchConceptsMajor public health concernType 2 diabetesOverview of therapiesHost of comorbiditiesTreatment of diabetesPublic health concernEvidence-based informationAntidiabetic agentsTherapeutic goalsDiabetes treatmentDiabetesOlder populationHealth concernOlder adultsPrevalent formTreatmentMedical picturesComorbiditiesTherapy
2002
Oral Antihyperglycemic Therapy for Type 2 Diabetes: Clinical Applications
Holmboe E. Oral Antihyperglycemic Therapy for Type 2 Diabetes: Clinical Applications. JAMA 2002, 287: 373-376. PMID: 11790217, DOI: 10.1001/jama.287.3.373.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiguanidesComorbidityDecision MakingDiabetes Mellitus, Type 2Drug Therapy, CombinationEnzyme InhibitorsEvidence-Based MedicineFemaleGlycoside Hydrolase InhibitorsHumansHypoglycemic AgentsInsulinMaleMiddle AgedPatient Education as TopicPatient ParticipationPhysician-Patient RelationsPractice Guidelines as TopicSulfonylurea CompoundsThiazolesConceptsType 2 diabetesPharmacological treatmentEffective patient self-managementOral antihyperglycemic therapyPharmacological treatment of diabetesPharmacological treatment regimensPatient self-managementOral agentsEvidence-based medicineTreatment regimensAntihyperglycemic therapyMultisystem disorderDiabetic patientsGlycemic controlSelf-ManagementTreatment of diabetesIndividual patientsPatientsMultidisciplinary carePatient preferencesClinical applicationDiabetesPhysiciansComplex decision makingAgents
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