2008
Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment
Lemmon M. Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment. 2008 DOI: 10.21236/ada488172.Peer-Reviewed Original ResearchEGF receptor family membersEGF receptor signalingEGF-like ligandsReceptor family membersNew structural informationFruit flyYeast surface displayEGF receptorEGFR ligandsSecreted inhibitorsProtein scaffoldsReceptor signalingFunctional fragmentsSurface displayHuman EGFProtein therapeuticsTherapeutic designGrowth factorStructural informationNew therapeuticsExperimental approachStructure determinationFamily membersDrosophilaReceptors
2007
Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment
Lemmon M. Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment. 2007 DOI: 10.21236/ada471085.Peer-Reviewed Original ResearchEGF receptor family membersEGF receptor signalingEGF-like ligandsReceptor family membersNew structural informationFruit flyYeast surface displayEGF receptorSecreted inhibitorsEGFR ligandsProtein scaffoldsReceptor signalingFunctional fragmentsSurface displayHuman EGFProtein therapeuticsTherapeutic designGrowth factorNew therapeuticsStructural informationExperimental approachStructure determinationFamily membersDrosophilaReceptors
1995
Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin
Korutla L, Cheung J, Medelsohn J, Kumar R. Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin. Carcinogenesis 1995, 16: 1741-1745. PMID: 7634398, DOI: 10.1093/carcin/16.8.1741.Peer-Reviewed Original ResearchConceptsGrowth stimulatory pathwaysTumor cell growthTime-dependent mannerAnti-proliferative strategyTyrosine phosphorylationEpidermal growth factorEpidermal growth factor receptor tyrosine phosphorylationCurcumin treatmentActivation of EGFCalcium releaseStimulatory pathwayReceptor tyrosine phosphorylationTreatment of cellsEGF receptor phosphorylationKinase inhibitorsGrowth factorSurface expressionReceptor phosphorylationHuman EGFCurcuminEGFInhibition of EGFPotent inhibitorActivationCell growth
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