2013
Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice
Weerachayaphorn J, Luo Y, Mennone A, Soroka CJ, Harry K, Boyer JL. Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice. Journal Of Hepatology 2013, 60: 160-166. PMID: 23978715, PMCID: PMC4054607, DOI: 10.1016/j.jhep.2013.08.015.Peer-Reviewed Original ResearchConceptsBile duct ligationBDL miceLiver injuryControl miceBile duct-ligated miceBile flow rateBile duct obstructionHepato-protective effectsSmooth muscle actin expressionLiver function markersSevere liver damageBile acid-independent flowHigher bile flowMatrix metalloproteinases-9Hepatic stellate cellsCancer preventive agentsMuscle actin expressionPromising cancer-preventive agentBiliary pressureSerum aminotransferasesLiver histologyBDL groupPhase II detoxificationPortal fibroblastsProfibrogenic genes
2001
Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat
Lee J, Azzaroli F, Wang L, Soroka C, Gigliozzi A, Setchell K, Kramer W, Boyer J. Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat. Gastroenterology 2001, 121: 1473-1484. PMID: 11729126, DOI: 10.1053/gast.2001.29608.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsBile Acids and SaltsCarrier ProteinsCholestasisCommon Bile DuctFluorescent Antibody TechniqueKidneyLigationLiverMaleMicrovilliMitochondrial ProteinsOrganic Anion Transporters, Sodium-DependentRatsRats, Sprague-DawleyRibosomal ProteinsRNA, MessengerSaccharomyces cerevisiae ProteinsSymportersConceptsBile salt excretionCommon bile duct ligationBile salt transportersBile duct ligationSalt excretionObstructive cholestasisSalt transportersDuct ligationCommon bile duct obstructionKidney 14 daysBile duct obstructionBile salt transport proteinsSerum bile saltsBrush border membrane vesiclesProtein 2 expressionBile salt transportSodium-dependent uptakeExtrahepatic pathwaysLiver injuryDuct obstructionTissue immunofluorescenceBorder membrane vesiclesTransporter messenger RNAExtrahepatic tissuesTotal liver
2000
Noncalculous biliary obstruction in the child and adolescent11No competing interests declared.
Pryor J, Volpe C, Caty M, Doerr R. Noncalculous biliary obstruction in the child and adolescent11No competing interests declared. Journal Of The American College Of Surgeons 2000, 191: 569-578. PMID: 11085737, DOI: 10.1016/s1072-7515(00)00725-0.Peer-Reviewed Original ResearchConceptsYears of ageBiliary obstructionAge groupsPatients 21 yearsBile duct obstructionCommon duct stonesCases of cholecystitisHigh-risk groupObese adolescent girlsCourse of treatmentAbsence of stonesAcalculous cholecystitisYounger patientsDuct stonesMale patientsObstructive jaundiceDuct obstructionPatient 1Pediatric casesAdult casesBiliary operationsDiagnostic dilemmaTract diseaseMayo ClinicCommon cause
1996
Malignant hepatic hilar tumors: can ultrasonography be used as an alternative to angiography with CT arterial portography for determination of resectability?
Hann L, Fong Y, Shriver C, Botet J, Brown K, Klimstra D, Blumgart L. Malignant hepatic hilar tumors: can ultrasonography be used as an alternative to angiography with CT arterial portography for determination of resectability? Journal Of Ultrasound In Medicine 1996, 15: 37-45. PMID: 8667482, DOI: 10.7863/jum.1996.15.1.37.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAngiographyAtrophyBile Duct NeoplasmsBile Ducts, IntrahepaticCholestasis, IntrahepaticFemaleHumansLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessPatient Care PlanningPortal VeinPortographyTomography, X-Ray ComputedUltrasonography, DopplerUltrasonography, Doppler, ColorConceptsCT portographyLevel of biliary obstructionSurgical pathology correlationMalignant hilar obstructionCT arterial portographyDetermination of resectabilityPortal vein involvementDiagnosis of atrophyAlternative to angiographySpectral Doppler techniquesBile duct obstructionExtrahepatic metastasesVein involvementHilar obstructionArterial portographyConsecutive patientsParenchymal invasionVenous invasionDuct obstructionBiliary obstructionDrainage catheterHepatic involvementPathologic correlationPortographyUltrasonography
1989
Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis.
Anderson J, Glade J, Stevenson B, Boyer J, Mooseker M. Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis. American Journal Of Pathology 1989, 134: 1055-62. PMID: 2719075, PMCID: PMC1879891.Peer-Reviewed Original ResearchConceptsZO-1 proteinZO-1Tight junctionsConsecutive daily subcutaneous injectionsFrozen sectionsReflux of bileDaily subcutaneous injectionsBile duct obstructionCommon bile ductMale Sprague-DawleyHepatocyte tight junctionsBile duct ligation resultsTight junction protein ZO-1Cholestatic modelsDuct obstructionBile ductSubcutaneous injectionCholestatic liverRat modelEthinyl estradiolSprague-DawleyProtein ZO-1Immunoperoxidase stainingZO-1 stainingImmunohistochemical localizationGentamicin nephrotoxicity in extrahepatic cholestasis: Modulation by dietary calcium
Vakil N, Abu‐Alfa A, Mujais S. Gentamicin nephrotoxicity in extrahepatic cholestasis: Modulation by dietary calcium. Hepatology 1989, 9: 519-524. PMID: 2925154, DOI: 10.1002/hep.1840090402.Peer-Reviewed Original ResearchConceptsDietary calcium supplementationGentamicin nephrotoxicityCalcium supplementationLigation animalsExtrahepatic cholestasisCommon bile duct ligation groupCommon bile duct ligation ratsBile duct ligation groupCommon bile duct obstructionBile duct ligation ratsMale Sprague-Dawley ratsUrinary calcium excretionHigh calcium dietBile duct obstructionBile duct ligationSprague-Dawley ratsCourse of therapyExperimental extrahepatic cholestasisSevere azotemiaCalcium excretionConcurrent administrationDuct obstructionGentamicin administrationSham ratsDietary calcium
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