Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons
Satta R, Maloku E, Zhubi A, Pibiri F, Hajos M, Costa E, Guidotti A. Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 16356-16361. PMID: 18852456, PMCID: PMC2570996, DOI: 10.1073/pnas.0808699105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA MethylationDown-Regulationgamma-Aminobutyric AcidGene Expression Regulation, EnzymologicGlutamate DecarboxylaseHippocampusMaleMiceNeuronsNicotinePromoter Regions, GeneticReceptors, CholinergicReelin ProteinRNA, MessengerTime FactorsUp-RegulationConceptsGABAergic neuronsFrontal cortexGABAergic interneuronsSchizophrenia patientsMedium spiny GABAergic neuronsDNMT1 expressionNicotinic receptor populationsStriatal GABAergic neuronsBlood-brain barrierHippocampal GABAergic interneuronsNicotine-induced decreasesDifferent cortical layersMouse frontal cortexDNA methyltransferase 1 expressionDNMT1 mRNA expressionSmoking habitsTobacco smokingReceptor dysfunctionMuscarinic receptorsSame dosesReceptor populationMethyltransferase 1 expressionCortical layersMRNA expressionHypermethylation of promoters
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