2013
Design, Synthesis, and Antiviral Evaluation of Chimeric Inhibitors of HIV Reverse Transcriptase
Iyidogan P, Sullivan T, Chordia M, Frey K, Anderson K. Design, Synthesis, and Antiviral Evaluation of Chimeric Inhibitors of HIV Reverse Transcriptase. ACS Medicinal Chemistry Letters 2013, 4: 1183-1188. PMID: 24900627, PMCID: PMC4027223, DOI: 10.1021/ml4002979.Peer-Reviewed Original ResearchH-phosphonatesLow nanomolar antiviral potencyReduced HIV replicationInhibitors of HIV reverse transcriptasePolymethylene linkerHIV replicationTMC derivativesAnti-HIV AgentsAntiviral evaluationAntiviral activity profileChimeric inhibitorsHIV reverse transcriptaseCell-based assaysAntiviral potencyReverse transcriptaseIC50 valuesCellular levelNucleosideInhibitorsThymidinePolymethylene
1988
Human Keratinocytes Catabolize Thymidine
Schwartz P, Kugelman L, Coifman Y, Hough L, Milstone L. Human Keratinocytes Catabolize Thymidine. Journal Of Investigative Dermatology 1988, 90: 8-12. PMID: 3335793, DOI: 10.1111/1523-1747.ep12462412.Peer-Reviewed Original ResearchConceptsHuman keratinocytesHuman neonatal foreskinHuman neonatal foreskin keratinocytesNeonatal foreskin keratinocytesCutaneous diseaseSoluble extractsGuinea pigsNeonatal foreskinKeratinocyte proliferationForeskin keratinocytesStratified culturesRate of incorporationAdult skinRadioactive thymidineKeratinocytesThymidine analogueAmount of thymidineExogenous thymidineSpecies differencesThymidineHuman fibroblastsSkinCatabolismDifferent tissuesCulture medium
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