2022
Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury
Palikuqi B, Rispal J, Reyes E, Vaka D, Boffelli D, Klein O. Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury. Cell Stem Cell 2022, 29: 1262-1272.e5. PMID: 35931034, PMCID: PMC9387209, DOI: 10.1016/j.stem.2022.07.007.Peer-Reviewed Original ResearchConceptsLymphatic endothelial cellsIntestinal stem cellsCytotoxic injuryEndothelial cellsIntestinal stem cell nicheWnt signalingProliferation of intestinal stem cellsCrypt epithelial cellsSource of Wnt signalingNiche cellsEpithelial renewalProgenitor cellsIntestinal recoveryIntestinal repairEpithelial cellsNiche componentsStem cellsInjury statesIntestinal epitheliumInjurySecreted moleculesSmall intestineCellsRepair
2021
Good Neighbors: The Niche that Fine Tunes Mammalian Intestinal Regeneration.
Palikuqi B, Rispal J, Klein O. Good Neighbors: The Niche that Fine Tunes Mammalian Intestinal Regeneration. Cold Spring Harbor Perspectives In Biology 2021, 14: a040865. PMID: 34580119, PMCID: PMC9159262, DOI: 10.1101/cshperspect.a040865.Peer-Reviewed Original ResearchConceptsIntestinal stem cellsBone morphogenetic proteinReversal of cell fateSelf-RenewalStem cell-like propertiesIntestinal stem cell nicheIncreased bone morphogenetic proteinMature epithelial cell typesStem Cell Self-RenewalCell-like propertiesEpithelial cell lineagesStem-like cellsSingle-cell technologiesEpithelial cell typesCell Self-RenewalOrganoid co-culturesCell fateMouse modelIntestinal renewalMesenchymal nicheEpithelial cellsImmune systemStem cellsEndothelial cellsCrypt bottomMAP3K2-regulated intestinal stromal cells define a distinct stem cell niche
Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature 2021, 592: 606-610. PMID: 33658717, DOI: 10.1038/s41586-021-03283-y.Peer-Reviewed Original ResearchConceptsStem cell nicheR-spondin 1Intestinal stromal cellsCell nicheDistinct stem cell nichesIntestinal stem cell nicheStromal cellsIntestinal stem cellsStromal cell populationsTissue homeostasisReactive oxygen speciesIntestinal stemMolecular mechanismsAcute intestinal damageSpecific functionsPrimary cellular sourceStem cellsColon cryptsOxygen speciesCell populationsIntestinal injuryIntestinal damageNicheCellular sourceCells
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