2019
Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility
Srinivasan S, Das S, Surve V, Srivastava A, Kumar S, Jain N, Sawant A, Nayak C, Purwar R. Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility. Scientific Reports 2019, 9: 19930. PMID: 31882703, PMCID: PMC6934852, DOI: 10.1038/s41598-019-56447-2.Peer-Reviewed Original ResearchConceptsRho-Associated Protein KinaseMyosin light chain kinaseRegulates actomyosin contractilityMyosin light chainA-431 cellsActomyosin contractilityFocal adhesionsA-431Loss of migrationPhosphorylation of myosin light chainPhosphorylated myosin light chainPrimary keratinocytesLight chain kinaseMyosin light chain kinase expressionStress fibresCarcinoma cell linesProtein kinaseHuman primary keratinocytesSkin epithelial cellsKinaseMalignant skin cellsEpidermal carcinoma cell lineSkin cellsEpithelial skin cellsPhysiological processes
2012
Unravelling hair follicle–adipocyte communication
Schmidt B, Horsley V. Unravelling hair follicle–adipocyte communication. Experimental Dermatology 2012, 21: 827-830. PMID: 23163647, PMCID: PMC3507425, DOI: 10.1111/exd.12001.Peer-Reviewed Original Research
2011
Diagnosis in a dish: your skin can help your brain
Huttner A, Rakic P. Diagnosis in a dish: your skin can help your brain. Nature Medicine 2011, 17: 1558-1559. PMID: 22146459, DOI: 10.1038/nm.2599.Peer-Reviewed Original Research
2007
Insulin receptor substrate 1 (IRS‐1) plays a unique role in normal epidermal physiology
Sadagurski M, Nofech‐Mozes S, Weingarten G, White M, Kadowaki T, Wertheimer E. Insulin receptor substrate 1 (IRS‐1) plays a unique role in normal epidermal physiology. Journal Of Cellular Physiology 2007, 213: 519-527. PMID: 17508357, DOI: 10.1002/jcp.21131.Peer-Reviewed Original ResearchConceptsNull miceIRS-1IRS-1 null miceIRS-2Skin physiologySkin cellsNormal epidermal physiologyInsulin receptor substrate-1Primary skin cellsSkin differentiationIRS-2 proteinReceptor substrate-1Skin epidermal cellsInsulin actionAdvanced stageExpression of K1Histological analysisNull skinSkin sectionsInsulin receptor substrate (IRS) proteinsEpidermal physiologyMiceSkin keratinocytesMarked decreaseEffects of inactivationMice cloned from skin cells
Li J, Greco V, Guasch G, Fuchs E, Mombaerts P. Mice cloned from skin cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 2738-2743. PMID: 17299040, PMCID: PMC1815251, DOI: 10.1073/pnas.0611358104.Peer-Reviewed Original Research
2005
Gene Therapy for Autosomal Dominant Disorders of Keratin
Lewin AS, Glazer PM, Milstone LM. Gene Therapy for Autosomal Dominant Disorders of Keratin. Journal Of Investigative Dermatology Symposium Proceedings 2005, 10: 47-61. PMID: 16250209, DOI: 10.1111/j.1087-0024.2005.10207.x.Commentaries, Editorials and LettersMeSH KeywordsAnimalsDarier DiseaseDependovirusEctodermal DysplasiaEpidermolysis Bullosa SimplexGene SilencingGene TargetingGenes, DominantGenetic TherapyGenetic VectorsHumansKeratinsKeratoderma, PalmoplantarMiceMutationNails, MalformedOligonucleotides, AntisenseRNA InterferenceRNA, CatalyticRNA, Small InterferingConceptsRNA knockdown approachGene correctionGene therapyViral vectorsEpidermal skin cellsKeratin diseasesKnockdown approachRNA interferenceGene expressionEpidermolysis bullosa simplexToxic proteinsDominant mutationsGenetic diseasesGenetic therapiesKeratin filamentsEpidermal diseasesGenetic defectsTissue cultureSelective inhibitorSkin cellsAttractive alternativeAutosomal dominant disorderRecent innovationsDominant disorderNear future
2001
Regulation of Cutaneous Malignancy by γδ T Cells
Girardi M, Oppenheim D, Steele C, Lewis J, Glusac E, Filler R, Hobby P, Sutton B, Tigelaar R, Hayday A. Regulation of Cutaneous Malignancy by γδ T Cells. Science 2001, 294: 605-609. PMID: 11567106, DOI: 10.1126/science.1063916.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCarcinogensCell LineCytotoxicity, ImmunologicDimerizationEpidermisEpithelial CellsHistocompatibility Antigens Class IHumansImmunologic SurveillanceLigandsMembrane ProteinsMiceMice, Inbred C57BLMinor Histocompatibility AntigensMolecular Sequence DataNK Cell Lectin-Like Receptor Subfamily KProtein ConformationProtein FoldingReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicReceptors, Natural Killer CellRecombinant Fusion ProteinsReverse Transcriptase Polymerase Chain ReactionSkin NeoplasmsT-Lymphocyte SubsetsConceptsT cellsGammadelta cellsLocal T cellsNatural killer cellsΓδ T cellsGammadelta T cellsCytolytic T cellsSkin carcinoma cellsNKG2D engagementMultiple regimensKiller cellsCutaneous malignanciesCutaneous carcinogenesisEpithelial malignanciesRAE-1Human MICAMalignancyCarcinoma cellsSkin cellsCellsNKG2DRegimensMiceEpitheliumCarcinogenesis
1998
Psoralen photochemotherapy, clinical efficacy, and photomutagenicity: The role of molecular epidemiology in minimizing risks
Gasparro FP, Liao B, Foley PJ, Wang XM, McNiff J. Psoralen photochemotherapy, clinical efficacy, and photomutagenicity: The role of molecular epidemiology in minimizing risks. Environmental And Molecular Mutagenesis 1998, 31: 105-112. PMID: 9544188, DOI: 10.1002/(sici)1098-2280(1998)31:2<105::aid-em2>3.0.co;2-l.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaHuman squamous cell carcinomaP53 mutation spectrumMurine squamous cell carcinomaEfficacy of PUVATreatment of psoriasisP53 tumor suppressor geneMutation spectrumPsoriasis patientsUVB phototherapyClinical efficacyPsoralen photochemotherapyCell carcinomaTherapeutic historyPUVATumor progressionUVB exposureMolecular epidemiologyPatientsTumor suppressor geneHuman cancersCommon mutationsPsoriasisSkin cellsPhotochemotherapy
1997
An Unexpected Spectrum of p53 Mutations from Squamous Cell Carcinomas in Psoriasis Patients Treated with PUVA
Wang X, McNiff J, Klump V, Asgari M, Gasparro F. An Unexpected Spectrum of p53 Mutations from Squamous Cell Carcinomas in Psoriasis Patients Treated with PUVA. Photochemistry And Photobiology 1997, 66: 294-299. PMID: 9277151, DOI: 10.1111/j.1751-1097.1997.tb08658.x.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaCell carcinomaP53 mutationsTreatment of psoriasisType mutationsP53 tumor suppressor genePUVA patientsPsoriasis patientsUVB phototherapyImmune suppressionTherapeutic historyNormal controlsPatientsTumor progressionUVB exposureTumor suppressor geneCarcinomaSingle-strand conformational polymorphismLong-wavelength ultraviolet radiationHuman cancersPUVAPsoriasisSkin cellsPhotochemotherapyDipyrimidine sites
1992
Identification and Characterization of a Cell Surface Proteoglycan on Keratinocytes
Haggerty J, Bretton R, Milstone L. Identification and Characterization of a Cell Surface Proteoglycan on Keratinocytes. Journal Of Investigative Dermatology 1992, 99: 374-380. PMID: 1401993, DOI: 10.1111/1523-1747.ep12616087.Peer-Reviewed Original ResearchConceptsCore proteinCell-cell contactIntercellular spacesCore protein moleculesCell surface proteoglycansCell extractsSurface proteoglycansEnzymatic deglycosylationProteinProtein moleculesSmall formsProteoglycansEpicanWestern immunoblotCD44 familyWestern blotSkin cellsHeparan sulfateHuman keratinocytes
1988
Effects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture.
Messadi DV, Pober JS, Murphy GF. Effects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture. Laboratory Investigation 1988, 58: 61-7. PMID: 3121914.Peer-Reviewed Original ResearchConceptsShort-term organ cultureHLA-DRLangerhans cellsOrgan cultureT6-positive Langerhans cellsClass II major histocompatibility antigensImmune interferonClass II major histocompatibility moleculesEpidermal dendritic cellsCutaneous immune responsesDendritic cell populationsHLA-DR expressionSkin microvascular endothelial cellsMajor histocompatibility antigensMicrovascular endothelial cellsSkin cellsNewborn human foreskinMajor histocompatibility moleculesDendritic cellsInflammatory mediatorsDQ expressionHLA-DQOrgan culture systemHistocompatibility antigensImmune response
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