2012
Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma
Modi BG, Neustadter J, Binda E, Lewis J, Filler RB, Roberts SJ, Kwong BY, Reddy S, Overton JD, Galan A, Tigelaar R, Cai L, Fu P, Shlomchik M, Kaplan DH, Hayday A, Girardi M. Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma. Science 2012, 335: 104-108. PMID: 22223807, PMCID: PMC3753811, DOI: 10.1126/science.1211600.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsAryl Hydrocarbon HydroxylasesCarcinogensCarcinoma, Squamous CellCell Transformation, NeoplasticCells, CulturedCytochrome P-450 CYP1A1Cytochrome P-450 CYP1B1DNA DamageGenes, rasHumansKeratinocytesLangerhans CellsMiceMice, TransgenicSkin NeoplasmsT-LymphocytesConceptsLangerhans cellsDendritic cellsDMBA-induced DNA damageCutaneous chemical carcinogenesisEpidermal dendritic cellsLC-deficient miceT cell immunitySquamous cell carcinomaChemical carcinogenesisDMBA-transHras mutationsCell immunityCell carcinomaImmune cellsDNA damageTumor resistanceDMBAPrior incubationHuman keratinocytesCarcinogenesisUnderlying mechanismMicePotent carcinogenSkinPAH metabolism
1988
Effects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture.
Messadi DV, Pober JS, Murphy GF. Effects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture. Laboratory Investigation 1988, 58: 61-7. PMID: 3121914.Peer-Reviewed Original ResearchConceptsShort-term organ cultureHLA-DRLangerhans cellsOrgan cultureT6-positive Langerhans cellsClass II major histocompatibility antigensImmune interferonClass II major histocompatibility moleculesEpidermal dendritic cellsCutaneous immune responsesDendritic cell populationsHLA-DR expressionSkin microvascular endothelial cellsMajor histocompatibility antigensMicrovascular endothelial cellsSkin cellsNewborn human foreskinMajor histocompatibility moleculesDendritic cellsInflammatory mediatorsDQ expressionHLA-DQOrgan culture systemHistocompatibility antigensImmune response
1985
Depletion and Repopulation of Epidermal Dendritic Cells After Allogeneic Bone Marrow Transplantation in Humans
Murphy G, Merot Y, Tong A, Smith B, Mihm M. Depletion and Repopulation of Epidermal Dendritic Cells After Allogeneic Bone Marrow Transplantation in Humans. Journal Of Investigative Dermatology 1985, 84: 210-214. PMID: 3919109, DOI: 10.1111/1523-1747.ep12265149.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntibodies, MonoclonalAntigens, Differentiation, T-LymphocyteAntigens, SurfaceBone Marrow TransplantationChild, PreschoolEpidermal CellsEpidermisFemaleGraft vs Host DiseaseHistocompatibility Antigens Class IIHumansImmunoenzyme TechniquesInfantLangerhans CellsMaleMicroscopy, ElectronConceptsAllogeneic bone marrow transplantationBone marrow transplantationEpidermal dendritic cellsDendritic cellsMarrow transplantationHLA-DRHistologic evidence of graft-versus-host diseaseEvidence of graft-versus-host diseaseReturn of these cellsGraft-versus-host diseaseDepletion of dendritic cellsAbsence of dendritic cellsPretransplant conditioning regimensKinetics of Langerhans cellsConditioning regimensIa-likeSequential biopsiesLangerhans cellsHistological evidenceTransplantationT6 antigenMonoclonal antibodiesClinical diseaseRepopulationBiopsy
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