Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells
Inayat-Hussain S, Chan K, Rajab N, Din L, Chow S, Kizilors A, Farzaneh F, Williams G. Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells. Toxicology Letters 2009, 193: 108-114. PMID: 20026395, PMCID: PMC2828539, DOI: 10.1016/j.toxlet.2009.12.010.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, PhytogenicApoptosisBlotting, WesternCaspase 2Caspase InhibitorsComet AssayCytochromes cDNA DamageDNA Topoisomerases, Type IIEnzyme InhibitorsFlow CytometryGlutathioneGoniothalamusHumansJurkat CellsOligopeptidesOxidative StressProto-Oncogene Proteins c-bcl-2PyronesReactive Oxygen SpeciesSignal TransductionTetrazolium SaltsThiazolesConceptsCaspase-2 activityCaspase-2DNA damageZ-VDVAD-FMKBcl-2-independent pathwayJurkat T leukemia cellsOxidative stressCytochrome c releaseBcl-2Bcl-2 transfectantsJurkat T cellsCellular oxidative stressT leukemia cellsApoptosis upstreamBcl-2 protein expressionGoniothalamus spC releaseII-independent pathwayReactive oxygen speciesIndependent pathwaysJurkat cellsCancer cell linesApoptosisCell linesProtein expression
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