2018
Induction of a Senescence-Like Phenotype in Cultured Human Fetal Microglia During HIV-1 Infection
Chen N, Partridge A, Tuzer F, Cohen J, Nacarelli T, Navas-Martín S, Sell C, Torres C, Martín-García J. Induction of a Senescence-Like Phenotype in Cultured Human Fetal Microglia During HIV-1 Infection. The Journals Of Gerontology Series A 2018, 73: 1187-1196. PMID: 29415134, PMCID: PMC6093403, DOI: 10.1093/gerona/gly022.Peer-Reviewed Original ResearchConceptsHIV-Associated Neurocognitive DisordersHIV-1 infectionHuman fetal microgliaHIV-1Fetal microgliaSenescence-like phenotypeIL-8Effective anti-retroviral therapyHIV-1 pseudotypedAnti-retroviral therapyChronically infected patientsReactive oxygen speciesProduction of cytokinesSenescence-associated secretory phenotypeCaveolin-1 levelsMarkers of cellular senescenceIL-8 productionMarkers of senescenceElevated markersSupernatant transferInfected patientsATP-linked respirationPost-infectionIL-6Mitochondrial reactive oxygen species
2017
Astrocyte Senescence and Metabolic Changes in Response to HIV Antiretroviral Therapy Drugs
Cohen J, D’Agostino L, Wilson J, Tuzer F, Torres C. Astrocyte Senescence and Metabolic Changes in Response to HIV Antiretroviral Therapy Drugs. Frontiers In Aging Neuroscience 2017, 9: 281. PMID: 28900395, PMCID: PMC5581874, DOI: 10.3389/fnagi.2017.00281.Peer-Reviewed Original ResearchHIV-Associated Neurocognitive DisordersHAART drugsHuman astrocytesDevelopment of HIV-associated neurocognitive disordersTreatment induced cell cycle arrestHIV-infected patientsMetabolic changesNeurocognitive disordersAntiretroviral therapy treatmentPrimary cultures of human astrocytesAntiretroviral therapy drugsCultures of human astrocytesCell cycle inhibitor p21Senescence-associated beta-galactosidaseInduction of reactive oxygen speciesAntiretroviral therapyMarkers of senescenceCell cycle arrestAstrocyte senescenceHAARTTherapy drugsPrimary culturesSurvival rateIncreased glycolysisNeurocognitive impairment
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