2014
Novel Molecules
Vukelic V, Orias M. Novel Molecules. Clinical Hypertension And Vascular Diseases 2014, 47-55. DOI: 10.1007/978-1-4939-1982-6_5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAngiotensin II type 2 receptor agonistType 2 receptor agonistBlood pressure controlEnd-organ damageEndothelin receptor antagonistsAldosterone synthase inhibitorsNew therapeutic approachesSoluble epoxide hydrolase inhibitorsSoluble guanylyl cyclaseEpoxide hydrolase inhibitorAldosterone axisHypertension treatmentVasopeptidase inhibitorReceptor antagonistReceptor agonistRecombinant renalaseTherapeutic approachesNew agentsSynthase inhibitorAnimal modelsRenin inhibitorsPressure controlGuanylyl cyclaseAdverse effectsHydrolase inhibitors
2009
Is there a role for direct renin inhibitors in chronic kidney disease?
Peixoto AJ, Orias M. Is there a role for direct renin inhibitors in chronic kidney disease? Current Opinion In Nephrology & Hypertension 2009, 18: 397-403. PMID: 19584722, DOI: 10.1097/mnh.0b013e32832e3183.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic kidney diseaseBlood pressure controlKidney disease progressionRenin inhibitorsCardiovascular eventsKidney diseaseDisease progressionEffective blood pressure controlPressure controlHard renal endpointsEarly diabetic nephropathyNormal renal functionDirect renin inhibitorRandomized clinical trialsRenal endpointsStudy drugCardiovascular riskDiabetic nephropathyRenal functionRenal injuryImproved survivalClinical trialsAnimal modelsHuman studiesPatients
1991
Effects of endothelin on in vitro renin secretion
Moe O, Tejedor A, Campbell WB, Alpern RJ, Henrich WL. Effects of endothelin on in vitro renin secretion. American Journal Of Physiology 1991, 260: e521-e525. PMID: 2018117, DOI: 10.1152/ajpendo.1991.260.4.e521.Peer-Reviewed Original ResearchConceptsRat kidney cortical slicesRenin secretionKidney cortical slicesEndothelin-1Juxtaglomerular cellsRenin releaseCortical slicesRenin inhibitionBasal renin releaseVitro renin secretionBasal renin secretionRenal renin secretionEffects of endothelinIntracellular calcium bufferAddition of isoproterenolMechanism of actionRenin inhibitorsIsoproterenolSecretionCalcium bufferDistinct preparationsBAPTASimilar effectsDirect effectInhibition
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